| 黄酮类化合物抗心脑血管缺血性疾病作用的研究进展 |
| 投稿时间：2021-11-14 修订日期：2022-02-28 点此下载全文 |
| 引用本文：严啸东,郭美丽.黄酮类化合物抗心脑血管缺血性疾病作用的研究进展[J].药学实践杂志,2022,40(2):97~102 |
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| 基金项目:国家科技重大专项（2009ZX09102-131） |
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| 中文摘要:黄酮类化合物是一种广泛存在于传统中药中的次生代谢产物，拥有许多生物活性和药理作用。近年来，研究发现黄酮类化合物可以通过多种途径在缺血性脑卒中和缺血性心脏病的治疗中发挥有效的保护作用，同时对于其保护作用的机制也有了较为详细系统的阐释。比如黄酮类化合物可以在抗氧化、抑制炎症反应、细胞凋亡和自噬等病理生理机制中发挥有效作用。本文通过查阅国内外的相关文献，对黄酮类化合物抗心脑血管缺血性疾病的保护作用及其机制进行综述。旨在为抗心脑血管疾病药物的研究开发提供参考。 |
| 中文关键词:黄酮类化合物 缺血性心脏病 缺血性脑卒中 保护作用 作用机制 |
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| Research progress of the effect of flavonoids on cardiovascular and cerebrovascular ischemic diseases |
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| Abstract:Flavonoids are secondary metabolites that widely existing in traditional Chinese medicine. They have many biological activities and pharmacological effects. In recent years, studies have found that flavonoids can play an effective protective role in the treatments of ischemic stroke and ischemic heart disease through various ways. The mechanisms of their protective effects have been systematically explained in detail. For example, flavonoids can affect pathophysiological mechanisms such as antioxidant, inhibition of inflammatory response, apoptosis and autophagy pathway. This paper reviews the protective effect and mechanisms of the treatments of flavonoids on cardiovascular and cerebrovascular ischemic diseases by referring to relevant literatures. The purpose is to provide reference for future research and development of drugs for the treatments of cardiovascular and cerebrovascular diseases. |
| keywords:flavonoids ischemic heart disease ischemic stroke protective effect mechanism of action |
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