| 利巴韦林脂质体吸入粉雾剂的研制与初步评价 |
| 投稿时间：2020-04-14 修订日期：2020-09-07 点此下载全文 |
| 引用本文：方夏琴,檀华进,谭晓川,李鹤,张宇佳,郑稳生.利巴韦林脂质体吸入粉雾剂的研制与初步评价[J].药学实践杂志,2020,38(6):539~542 |
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| 基金项目:十三五国家“重大新药创制”科技重大专项资助（2018ZX09721003-009-003；2018ZX09721003-007-007） |
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| 中文摘要:目的 为解决利巴韦林存在的明显不良反应问题，研制利巴韦林脂质体吸入粉雾剂，并初步评价其质量特性。方法 采用薄膜分散法制备利巴韦林脂质体，再冻干制备成利巴韦林脂质体粉雾剂，并考察制剂的外观形态、流动性、松密度、包封率、复溶液粒径、聚合物分散指数、电位及亲水性。结果 利巴韦林脂质体粉雾剂形态、粒径、电位、流动性与亲水性均较好，能满足粉雾剂給药的基本要求。结论 应用该方法制备利巴韦林脂质体粉雾剂的制剂技术是可行的，为后续体内外研究提供制剂学技术依据。 |
| 中文关键词:利巴韦林 脂质体 冻干 粉雾剂 |
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| Preparation and preliminary evaluation of ribavirin liposome-powder inhaler |
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| Abstract:Objective In order to solve the obvious adverse reactions of ribavirin, to develop ribavirin liposome inhalation powder and to evaluate its quality characteristics.Methods The ribavirin liposomes were prepared by the thin film dispersion method, and then lyophilized to prepare ribavirin liposome powder. The appearance, fluidity, bulk density, encapsulation efficiency, particle size of the complex solution, PDI, potential and hydrophilicity were examined.Results Ribavirin liposome powder has good morphology, particle size, potential, fluidity and hydrophilicity, which can meet the basic requirements of powder medicine for drug administration.Conclusion The technique of preparing ribavirin liposome powder aerosol preparation by this method is feasible, and it provides the basic technology for future in vivo and in vitro studies. |
| keywords:ribavirin liposomal lyophilized powder inhalers |
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