| 甘地胶囊中马钱苷含量测定方法的优化 |
| 投稿时间：2018-06-01 修订日期：2018-09-10 点此下载全文 |
| 引用本文：魏昕,徐人杰,唐英,姚懁,徐阿晶,张健.甘地胶囊中马钱苷含量测定方法的优化[J].药学实践杂志,2018,36(6):551~553 |
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| 基金项目:上海市科委项目（15401901600；16401900500） |
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| 中文摘要:目的 建立HPLC法测定甘地胶囊中马钱苷的含量。方法 色谱柱为Waters Symmtry C18柱（4.6 mm×150 mm，5 μm）；流动相为乙腈-水（13∶87）；流速1.0 ml/min；检测波长240 nm。结果 马钱苷对照品在0.030 1~3.01 μg范围内呈良好的线性关系（r=0.999 9），平均加样回收率为99.62%，RSD为0.86%。结论 本方法简便、准确，重复性好，可用于甘地胶囊中马钱苷的含量测定。 |
| 中文关键词:甘地胶囊 马钱苷 含量测定 高效液相色谱 |
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| Optimization of assay method for loganin in Gandi capsules |
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| Abstract:Objective To establish a HPLC method for the assay of loganin in Gandi capsules. Methods The Waters Symmtry column C18 (4.6 mm×150 mm, 5 μm) was used with acetonitrile-water (13:87) as mobile phase. The flow rate was 1.0 ml/min and the detection wavelength at 240 nm. Results The calibration curves were linear within the range of 0.030 1-3.01 μg (r=0.999 9) for loganin. The average recovery and relative standard deviation of loganin were 99.62% and 0.86%. Conclusion This method is simple, practicable, accurate and fast. It can be used to assay loganin in Gandi capsules. |
| keywords:Gandi capsule loganin assay HPLC |
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