| 百蕊草亲水性化学成分研究 |
| 投稿时间：2017-12-04 修订日期：2018-01-17 点此下载全文 |
| 引用本文：宣伟东,范正平,胡水根,徐德东.百蕊草亲水性化学成分研究[J].药学实践杂志,2018,36(3):270~273 |
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| 基金项目:上海市卫生局局级科研课题（2012085） |
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| 中文摘要:目的 对百蕊草中亲水性化学成分进行研究。方法 采用硅胶柱色谱、SephadexLH-20凝胶柱色谱等分离手段，对百蕊草水提取物经AB-8大孔树脂吸附，50%乙醇洗脱的亲水性组分（TT50）进行分离纯化，应用核磁共振波谱分析、结合文献报道鉴定化合物结构。结果 从TT50中分离纯化得到6个化合物，分别鉴定为：山奈酚（1），紫云英苷（2），山奈酚-3，7-二-O-β-D-吡喃葡萄糖苷（3），山奈酚-3-O-L-吡喃鼠李糖基（1→2）-β-D-吡喃葡萄糖苷（4），山奈酚-3-O-L-吡喃鼠李糖基（1→2）-［6-O-乙酰基］-β-D-吡喃葡萄糖苷（5），芸香苷（6）。结论 TT50中主要成分为以山奈酚为母核的黄酮苷类化合物，化合物4、5为首次从百蕊草中分离得到。 |
| 中文关键词:百蕊草 化学成分 黄酮苷 |
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| Study on hydrophilic chemical constituents from Thesium Chinensis Turcz |
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| Abstract:Objective To investigate the hydrophilic chemical constituents from Thesium Chinensis Turcz. Methods The water extract of Thesium Chinensis Turcz. was adsorbed onto AB-8 resin column and eluted with 50% ethanol to give the hydrophilic portion TT50. TT50 was further separated and purified by repeated column chromatography on silica gel,Sephadex LH-20. The structures of these purified compounds were identified by NMR spectral analysis and comparison with the reported data. Results Six compounds were isolated and identified as kaempferol (1),kaempferol-3-O-glucoside (2),kaepmferol-3,7-di-O-β-D-glucopyranoside (3),kaempferol-3-O-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside (4),kaemperol-3-O-α-L-rhamnopyranosyl(1→2)-[6-O-acetyl]-β-D-glucopyranoside (5),rutinoside (6). Conclusion The main constituents of TT50 were kaempferol glycosides. Compounds 4 and 5 were isolated from this plant for the first time. |
| keywords:Thesium chinensis Turcz chemical constituents flavonoid glycosides |
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