| 青藤碱结构改造的研究进展 |
| 投稿时间：2017-10-09 修订日期：2017-12-29 点此下载全文 |
| 引用本文：李修政,赵庆杰,董家潇,姜云云,叶光明.青藤碱结构改造的研究进展[J].药学实践杂志,2018,36(3):204~209,214 |
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| 中文摘要:青藤碱是一种来源于防己科植物青风藤中的生物碱，在结构上属于异喹啉类，具有多种生物活性。在临床上主要用于治疗风湿性及类风湿性关节炎和心律失常等疾病。但由于其用药剂量大、对光/热不稳定、体内代谢快、易引起过敏反应，科研人员一直致力于对青藤碱进行结构修饰，以期开发出高效、低毒的青藤碱衍生物。对近年来青藤碱的结构修饰研究进展做一综述。 |
| 中文关键词:青藤碱 结构修饰 衍生物 |
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| Research progress in sinomenine structural modification |
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| Abstract:Sinomenine is an alkaloid found in the climbing plant Sinomenium acutum.Structurally, it belongs to the isoquinoline derivatives, which have various bioactivities.Clinically, it is used in the treatment for rheumatism, rheumatoid arthritis and arrhythmia, etc.Nevertheless, due to the need of large dose, photo and thermal instability, quick metabolism in vivo and highly allergic for some patients, scientists have committed to modify its structure to develop the highly effective and low toxic derivatives.In this paper, the recent advances in structural modification of sinomenine are reviewed. |
| keywords:sinomenine structural modification derivatives |
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