| 氟马西尼的药理、药效和剂型应用进展 |
| 投稿时间：2017-08-18 修订日期：2017-09-01 点此下载全文 |
| 引用本文：侯成,卢光照,李文清,邹豪.氟马西尼的药理、药效和剂型应用进展[J].药学实践杂志,2017,35(6):485~489 |
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| 基金项目:国家自然科学基金项目（30801441，81773278）；军队后勤科研重大项目（AWS14J011） |
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| 中文摘要:氟马西尼作为苯二氮GFDA1（BDZ）受体拮抗剂，能特异性结合中枢BDZ受体，减少γ-氨基丁酸（GABA）的释放，从而拮抗BDZ类、非BDZ类药物引起的抗焦虑、镇静催眠、麻醉等作用。根据其作用靶点和方式，就目前氟马西尼在临床、科研上的应用和剂型进展做一综述。 |
| 中文关键词:氟马西尼 药理学 药效学 剂型 |
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| Recent progress in pharmacology, efficacy and dosage forms of flumazenil |
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| Abstract:Flumazenil, a benzodiazepine antagonist, specifically binds the benzodiazepine receptors in central nervous system and reduces the release of gamma-aminobutyric acid. It is used for the reversal of sedative effects of benzodiazepine and benzodiazepine-induced anesthesia. In this article, the clinical applications of flumazenil and the developments of different dosage forms were reviewed. |
| keywords:flumazenil pharmacology pharmacodynamics dosage forms |
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