| 莫达非尼对小鼠自主活动的影响 |
| 投稿时间：2005-03-03 点此下载全文 |
| 引用本文：于佳玥,刘雨嵋,张晓冬.莫达非尼对小鼠自主活动的影响[J].药学实践杂志,2005,(3):156~157,175 |
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| 中文摘要:目的 研究莫达非尼对小鼠自主活动的影响,以评价莫达非尼对小鼠神经系统的作用.方法 应用计算机视频分析系统观察莫达非尼对雄性小鼠单位时间内活动的总活动度、平均速度和线性度的影响.结果 对照组在相同时间点相比,120mg/kg的莫达非尼可以显著升高小鼠单位时间内活动的总活动度、平均速度以及线性度.60mg/kg异丙嗪可以部分拮抗莫达非尼对小鼠自主活动的影响.结论 莫达非尼可以兴奋小鼠中枢神经系统,机制可能与胆碱能系统或5-HT系统有关. |
| 中文关键词:modafinil locomotor activity mice |
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| Effect of modafinil on locomotor activity in mice |
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| Abstract:Objective To observe the effect of modafinil on locomotor activity and on CNS in mice.Methods Male mice were used as subjects.Total range of motion, average velocity and linearity were evaluated fay locomotion activity video analysis system.Results Total range of motion, average velocity and linearity were significantly improved after ip 120 mg/kg Modafinil compared to saline treatment.The effect was partial antagonized by sc 60 mg/kg promethamine.Conclusion Modafinil can stimulate CNS in mice which may involve 5-HT system. |
| keywords:modafinil locomotor activity mice |
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