| 盐酸利多卡因注射液碱化后稳定性试验 |
| 投稿时间：2000-12-29 点此下载全文 |
| 引用本文：方强三,马永德,朱丽青,孙成春.盐酸利多卡因注射液碱化后稳定性试验[J].药学实践杂志,2001,(3):151~152,192 |
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| 中文摘要:目的 考察盐酸利多卡因注射液碱化后的稳定性。方法 盐酸利多卡因注射液配制成4种浓度的溶液,每个浓度分别加入不同量的5% NaHCO3溶液,测定碱化前后4种溶液不同时间的pH值及利多卡因的含量。结果 4种浓度的溶液碱化后随着加入的NaHCO3量的增加,其pH值也逐渐增加,与碱化前相比较均有明显升高。百分含量随着时间的延长,均有显着上升;但随着加入NaHCO3量的增加含量显着下降,放置24h有针状结晶析出。结论 碱化时加NaHCO3量最好在0.5～2.0ml之间,碱化后放置时间不宜过长。 |
| 中文关键词:盐酸利多卡因 碱化 稳定性 |
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| Stability of lidocaine hydrochloride injection after alkalinizing |
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| Abstract:OBJECTIVE To study the stability of lidocaine hydrochloride after alkalinzing.METHODS Lidocaine hydrochloride injection was diluted 4 kinds of concentration.Each sample was added 5% NaHCO3 with different amounts.The pH and concentration of lidocaine were determined in those special alkaline environment in different time.RESULTS The pH of 4 kinds of alkaline lidocaine were remarkably higher than before with the
increase of 5% NaHCO3.The concentration of lidocaine were remarkably increased by time.But the more 5%
NaHCO3 added to,the less the concentration of lidocaine was notability.There was some needle-crystal in the solution after 24 hours.CONCLUSION The best amount of 5% NaHCO3 to add in is between 0.5ml to 2.0ml,and lidocaine hydrochloride injection couldnt put by for long time after alkalized. |
| keywords:lidocaine hydrochloride alkalinization stability |
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