| 复方丹参注射液对银屑病患者血中红细胞指数和脂质过氧化水平的影响 |
| 投稿时间：1999-10-15 点此下载全文 |
| 引用本文：赵喜荣,贾义星,郝晓菁,宋守宗.复方丹参注射液对银屑病患者血中红细胞指数和脂质过氧化水平的影响[J].药学实践杂志,2000,(2):77~79,90 |
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| 中文摘要:目的 通过对45例银屑病患者应用复方丹参液治疗前后红细胞4项指数及血中MDA、SOD、GSH-PX含量的研究,探讨复方丹参液对它们的影响及银屑病的发病机理。方法 测定银屑病患者用药前后血中红细胞的4项指数及MDA、SOD、GSH-PX的含量,并与健康组比较。结果 银屑病患者红细胞4项指数均有异常,以平均红细胞体积(MCV)和平均红细胞血红蛋白浓度(MCHC)改变最为显着(P<0.05);血浆MDA水平较高,红细胞SOD、GSH-PX活性下降,而应用复方丹参液治疗后,MCV和MCHC值均有所改善,接近健康组;MDA水平下降,SOD、GSH-PX活性升高。 |
| 中文关键词:银屑病 血由基 过氧化脂质类 红细胞指数 复方丹参注射液 |
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| Effect of Fufang Danshen injection on red cell indexes and the level of lipid-peropxidation in patients with psoriasis |
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| Abstract:OBJECTIVE To study the effects of Fufang Danshen injection on indexes of red cell and malonyldialdehyde (MDA) content,superoxide enzyme (SOD) and glutathione-peroxidase (GHS-PX) activities in patients with psoriasis.METHODS Fourty-five psoriasis patients were treated with Fufang danshen,injection,compared with fifty normal subjects.We measured their four indexes of red cell,MDA,SOD and GSH-PX of blood.RESULTS The four indexes of psoriasis are all abnormal,especially the levels of mean cell volume (MCV) and mean concentration of hemoglobin (MCHC) (P<0 05).After treated with Fufang Dansen MCV and MCHC of red cell changed obviously,restored to normal levels.The level of MDA in patients increased and the activities of SOD,GSH-PX were decreased.After using Fufang Danshen the level of MDA decreased and SOD,GSH-PX were increased and P<0 05.CONCLUSION The abnormal degree of red cell in four indexes,MDA,SOD and GSH-PX were correlated with the stage of this disease,which suggest that abnormality of indexes of red cell and lipid-peroxidation may play a certain role in the pathogenesis of psoriasis,and this may be used as important reference indexes to judge the severity of the disease and evaluate the therapeutic effect of Fufang Danshen. |
| keywords:psoriasis free radical lipid peroxides red cell index Fufang Danshen injection |
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