| 苦参碱及衍生物的抗炎作用及其机制研究进展 |
| 投稿时间：2024-06-19 修订日期：2024-11-16 点此下载全文 |
| 引用本文：陶宫佳,陈林林,宋泽成,刘梦肖,王彦.苦参碱及衍生物的抗炎作用及其机制研究进展[J].药学实践杂志,2025,43(4):163~168 |
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| 基金项目:国家自然科学基金（81772124）；上海市“科技创新行动计划”生物医药科技支撑专项（20S11902900） |
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| 中文摘要:苦参碱是从中药植物苦参中分离提取的一种生物碱化合物，具有抗肿瘤、抗炎和抗病毒等作用，由于体内活性低、疗效时间短、毒副作用大等因素，其临床应用受到限制。为解决这一问题，药物专家对苦参碱的结构进行修饰获得其衍生物，以改善其缺点。目前，对苦参碱及衍生物抗肿瘤的研究比较多，在炎症性相关疾病中的研究还有待进一步加强。该文综述了苦参碱及衍生物在改善炎症性疾病中的作用及机制的研究进展，为苦参碱类药物研发提供线索。 |
| 中文关键词:苦参碱 衍生物 抗炎作用 信号通路 |
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| Research progress on anti-inflammatory effect and mechanism of matrine and its derivatives |
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| Abstract:Matrine is an alkaloid compound isolated and extracted from the traditional Chinese medicinal plant Sophora flavescens, which has anti-tumor, anti-inflammatory, and anti-viral effects. However, its clinical application has been limited due to its low in vivo activity, short duration of efficacy, and significant toxic side effects. In response to this challenge，pharmaceutical experts modified the structure of Matrine to obtain derivatives that addressed its limitations. Currently, research on the anti-tumor effects of Matrine and its derivatives is more prevalent, while research in inflammatory-related diseases still needs further strengthening.The progress on the role and mechanism of Matrine and its derivatives in inflammatory diseases were summarized in this paper, which offered valuable insights for the development of therapeutic agents based on Matrine. |
| keywords:Matrine derivatives anti-inflammatory action signal pathway |
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