| 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 |
| 投稿时间：2023-11-14 修订日期：2024-03-01 点此下载全文 |
| 引用本文：唐淑慧,凤美娟,薛智霞,鲁桂华.帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究[J].药学实践杂志,2024,42(5):217~222 |
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| 基金项目:海军军医大学护理“筑原”人才项目（2022KYZ08）；上海护理学会专项课题（2023JL-B08） |
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| 中文摘要:目的 探讨帕博利珠单抗治疗免疫相关不良反应与中医体质之间的相关性。方法 选取初次确诊为非小细胞肺癌的患者共110例，在首次接受帕博利珠单抗免疫治疗时采用一般资料调查表、中医体质分类与判定量表及《免疫相关不良反应随访记录册》和患者记录的《自我感受日记》，对患者的中医证候和不良反应进行调查和分析。结果 非小细胞肺癌患者中4种中医体质较多：平和质48例（43.64%），偏颇体质中，阳虚质30例（27.27%）、气虚质20例（18.18%）、阴虚质12例（10.91%）。气虚质和阳虚质更容易发生疲乏，阳虚质更易发生皮疹；气虚质和阴虚质更易发生瘙痒；阳虚质更易发生腹泻；平和质的非小细胞肺癌患者不易发生免疫相关不良反应。结论 中医体质与irAEs相关，可从中医体质方面预测免疫相关不良反应的发生，早期干预不良反应。 |
| 中文关键词:非小细胞肺癌 中医体质 免疫治疗 免疫相关不良反应 |
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| Correlation between immune related adverse reactions in patients treated with pembrolizumab and Traditional Chinese Medicine constitution |
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| Abstract:Objective To explore the correlation between the immune related adverse （irAEs） reactions in patients treated with pembrolizumab and traditional Chinese Medicine （TCM） constitution. Methods A total of 110 patients diagnosed with non-small cell lung cancer for the first time were selected. When receiving pembrolizumab immunotherapy for the first time, a general information questionnaire, a TCM constitution classification and judgment scale, an immune related adverse reaction follow-up record book, and a patient's self-perception diary were used to investigate and analyze the TCM syndrome and adverse reactions of the patients. Results Among non-small cell lung cancer patients, there were more than four TCM constitutions, with 48 cases （43.64%） having a calm constitution, 20 cases （18.18%） having a biased constitution, 30 cases （27.27%） having a yang deficiency constitution, and 12 cases （10.91%） having a yin deficiency constitution. Qi deficiency and Yang deficiency were more prone to fatigue, while Yang deficiency was more prone to rash; Qi deficiency and Yin deficiency were more prone to itching; Yang deficiency was more prone to diarrhea; Non-small cell lung cancer patients with mild constitution were less prone to immune related adverse reactions. Conclusion TCM constitution is related to irAEs, which could predict the occurrence of immune related adverse reactions from the perspective of TCM constitution and intervene in adverse reactions early. |
| keywords:non-small cell lung cancer constitution of Traditional Chinese Medicine immunotherapy immune related adverse reactions |
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