| Keap1-Nrf2通路在炎症疾病中的研究进展 |
| 投稿时间：2024-05-09 修订日期：2024-12-26 点此下载全文 |
| 引用本文：周文艳,胡珊珊,张万年,庄春林.Keap1-Nrf2通路在炎症疾病中的研究进展[J].药学实践杂志,2025,43(3):97~108,116 |
| 摘要点击次数: 79 |
| 全文下载次数: 81 |
|
| 基金项目:国家自然科学基金“优秀青年基金”资助项目（82022065） |
|
| 中文摘要:Kelch样环氧氯丙烷相关蛋白-1-核因子e2相关因子2（Keap1-Nrf2） 通路已被证实是应对氧化应激的重要防御机制，调控该系统或许能成为众多疾病的有效治疗策略。主要探讨了Keap1-Nrf2通路在炎症疾病中的研究进展，介绍了Keap1-Nrf2通路的基本组成成分及激活机制，阐述了Keap1-Nrf2通路调控炎症与NF-κB通路、HO-1之间的影响、与炎症介质和酶的表达、炎症小体之间的关系。介绍了靶向Keap1-Nrf2通路的天然产物来源抑制剂、小分子抑制剂以及临床进展，探讨了Keap1-Nrf2通路在炎症治疗中的潜在应用价值。 |
| 中文关键词:Keap1 Nrf2 炎症 作用机制 抑制剂 |
| |
| Research progresses on Keap1-Nrf2 pathway in inflammatory diseases |
|
|
| Abstract:The Keap1-Nrf2 pathway has been shown to be an important defense mechanism against oxidative stress, which may be an effective therapeutic strategy for many diseases. The research progresses on Keap1-Nrf2 pathway in inflammatory diseases were mainly reviewed. The basic components and activation mechanism of Keap1-Nrf2 pathway were introduced. The relationship between Keap1-Nrf2 pathway and the crosstalk between NF-κB pathway and HO-1 pathway, the expression of inflammatory mediators and enzymes, and inflammatory bodies were expounded. Natural product-derived inhibitors, small molecule inhibitors targeting Keap1-Nrf2 pathway and their clinical progress were introduced, and the potential application value of Keap1-Nrf2 pathway in the treatment of inflammation was discussed. |
| keywords:Keap1 Nrf2 mechanism of action inflammation inhibitor |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
| 关闭 |
