| Abstract:Objective To analyze the adverse reaction reports of drug-induced liver injury in recent ten years, explore the characteristics and related rules of drug-induced liver injury, and provide reference for clinical safe drug use. Methods We collected ADRs in our hospital from 2011 to 2021 which belongde to drug-induced liver injuries, and carried on Pareto analysis . Results In 259 ADR reports, The most common type of drug-derived liver injury was hepatocellular injury (37.84%). The age of drug-induced liver injury was mainly over 46 years, totaling 195 (75.28%). Drugs were mainly distributed in cardiovascular system medicine (44.02%), anti-infective medicine (23.94%) and anti-tumor medicine (11.58%). Among the cardiovascular drugs, atorvastatin calcium 40mg and over were the highest proportion, with 53 cases (46.49%). The main anti-infectious drugs were cephalosporins (29.0%), carbapenem (19.4%)， antifungal (17.7%) and quinolones (11.29%). Adverse reactions occurred within 7 days (69.88%), the duration of adverse reactions was 1-2 weeks (31.66%), and most patients improved (47.88%) or cured (37.07%). Conclusion For middle-aged and elderly patients, when the application of cardiovascular system drugs, anti-infective drugs or anti-tumor drugs, it is necessary to monitor the liver function changes of patients for at least 7 days . If there are abnormalities, the drugs should be stopped or given treatment in time, so as to avoid the progress of drug-induced liver injury. |
