| 麝香保心丸“异病同治”2型糖尿病和冠心病的网络药理学作用机制研究 |
| 投稿时间：2023-05-22 修订日期：2023-11-23 点此下载全文 |
| 引用本文：朱子凡,王智聪,谢彬,柳润辉.麝香保心丸“异病同治”2型糖尿病和冠心病的网络药理学作用机制研究[J].药学实践杂志,2024,42(4):173~180 |
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| 基金项目:国家自然科学基金项目（82073981） |
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| 中文摘要:目的 基于网络药理学方法研究麝香保心丸“异病同治”2型糖尿病（T2DM）和冠心病（CHD）的作用机制。方法 运用中药系统药理学数据库与分析平台（TCMSP）、中药成分数据库（TCMID）、中医药百科全书数据库（ETCM）和BATMAN-TCM数据库筛选麝香保心丸中七味中药的化学成分和作用靶点，利用DisGeNET和GeneCards数据库获取与CHD和T2DM相关的疾病靶点。运用Cytoscape3.8.2软件构建“药物-成分-靶点”网络图，利用STRING数据库构建蛋白互作（PPI）网络图，利用DAVID在线数据库对麝香保心丸治疗T2DM和CHD的共同作用靶点进行GO生物过程分析和KEGG通路富集分析。结果 共筛选出麝香保心丸治疗T2DM和CHD的潜在活性成分101个，对应229个靶点。网络分析结果表明，麝香保心丸治疗T2DM和CHD的共同主要成分可能是鹅去氧胆酸、熊去氧胆酸、肉桂醛、胆汁酸、肉桂酸及人参皂苷类成分。通路富集分析结果显示，麝香保心丸“异病同治”T2DM和CHD的作用机制可能与抑制炎症反应和氧化应激有关。结论 麝香保心丸可通过多成分、多靶点、多途径发挥“异病同治”T2DM和CHD的作用，为麝香保心丸的临床应用及进一步研究提供理论基础。 |
| 中文关键词:麝香保心丸 2型糖尿病 冠心病 异病同治 网络药理学 |
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| Mechanisms of Shexiang Baoxin Pill in homo-therapy for heteropathy in type 2 diabetes mellitus and coronary heart disease based on network pharmacology |
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| Abstract:Objective To probe into the mechanism of Shexiang Baoxin Pill in homo-therapy for heteropathy for type 2 diabetes mellitus （T2DM） and coronary heart disease （CHD） based on network pharmacology. Methods All chemical components and action targets of these seven traditional Chinese medical in Shexiang Baoxin Pill were screened by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform （TCMSP）, Traditional Chinese Medicines Integrated Database （TCMID）, The Encyclopedia of Traditional Chinese Medicine （ETCM） and BATMAN-TCM platform, and the DisGeNET and GeneCards databases were used to obtain CHD and T2DM-related Disease targets. The “drug-component-target” network map was constructed by Cytoscape 3.8.2 software, the protein-protein interaction （PPI） network map was constructed by STRING database, and the GO biological process analysis and KEGG pathway enrichment analysis were performed on the common targets of Shexiang Baoxin Pill for T2DM and CHD using DAVID online database. Results A total of 101 potential active ingredients for the treatment of T2DM and CHD in Shexiang Baoxin Pill were screened out, corresponding to 229 targets. Network analysis results showed that the common main active ingredients in Shexiang Baoxin Pill for treating T2DM and CHD might be chenodeoxycholic acid, ursodeoxycholic acid, cinnamic aldehyde, bile acids, cinnamic acid, and ginsenosides. The results of pathway enrichment analysis showed that the mechanism of action of Shexiang Baoxin Pill in the treatment of type 2 diabetes and coronary heart disease in treating T2DM and CHD might be related to the inhibition of inflammatory response and oxidative stress. Conclusion Shexiang Baoxin Pill could play a role in treating CHD and T2DM through multiple components, multiple targets and multiple pathways, which provided a certain theoretical basis for the clinical application and further research of Shexiang Baoxin Pill. |
| keywords:Shexiang Baoxin Pill type 2 diabetes mellitus coronary heart disease homo-therapy for heteropathy network pharmacology |
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