| 复方黑参滴丸与复方黑参丸药效学实验比较研究 |
| 投稿时间：2024-04-02 修订日期：2024-10-17 点此下载全文 |
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| 基金项目:军队医疗机构制剂标准提高科研专项课题(13ZJZ02) |
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| 中文摘要:目的：研究复方黑参滴丸治疗慢性咽炎的药效学作用,并与传统制剂复方黑参丸进行比较。方法：选取健康Wistar大鼠60只,随机分为空白组、阳性对照组、治疗组。用1%角叉菜胶溶液注入每只大鼠的右后足爪皮下,测定致炎后1.0、2.0、3.0、4.0、5.0、6.0h每只大鼠的足跖肿胀厚度,计算每只大鼠的足跖肿胀率。通过大鼠的足趾肿胀实验模型,分别观察滴丸剂与丸剂两种剂型对角叉菜胶所致大鼠足跖肿胀的抑制作用；选取健康昆明种小鼠60只,随机分为空白组、阳性对照组、治疗组。连续灌胃给药4天后,小鼠腹腔注射0.5% NaHCO3酚红溶液,30分钟后处死小鼠,剥离出气管,用5%NaHCO3溶液冲洗,取冲洗液,置于紫外分光光度计中,在546nm波长处测定吸光度,计算相对应的酚红浓度。通过小鼠的酚红祛痰实验,对比滴丸剂与丸剂两种剂型对实验性小鼠呼吸道酚红分泌量的影响差别；结果：大鼠足趾肿胀实验结果表明：与空白实验组相比较,5个供试品液组(咽炎片组、复方黑参丸组,复方黑参滴丸低、中、高组)对角叉菜胶所引起的大鼠急性足跖肿胀均有显著的抑制作用。与复方黑参丸(传统剂型)组比较,复方黑参滴丸(改进剂型)高剂量组有显著性差异。小鼠酚红祛痰实验结果表明：与空白组相比较,4个供试品液组(复方黑参滴丸低、高三个剂量组、复方黑参丸组、咽炎片组)均能增加小鼠酚红分泌量。复方黑参滴丸(改进剂型)与复方黑参丸(传统剂型)对小鼠酚红分泌量的影响无显著性差异。 |
| 中文关键词:复方黑参滴丸 复方黑参丸 抗炎作用 祛痰作用 |
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| Comparative study of pharmacodynamic experiments on Compound HeiShen Drop pills and Compound HeiShen pills |
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| Abstract:Objection: Study and compare the pharmacodynamics in the treatment of chronic pharyngitis between Compound Heishen pills and Compound Heishen Drop pills. Methods: Sixty healthy Wistar rats were randomly divided into blank group, positive control group and treatment group. The foot swelling thickness of each rat was measured at 1.0,2.0,3.0,4.0,5.0 and 6.0h after inflammation, and the foot swelling rate of each rat was calculated. Through the experimental model of rat toe swelling, the inhibition of foot swelling induced by carrageenan was observed by two dosage forms: drop pill and pill. Sixty healthy Kunming mice were randomly divided into blank group, positive control group and treatment group. After 4 days of continuous intragastric administration, the mice were intraperitoneally injected with 0.5%NaHCO3 phenol red solution. After 30min, the mice were sacrificed, their trachea was dissected and washed with 0.5%NaHCO3 solution. The washing solution was put int ultraviolet spectrophotometer, and the absorbance was measured at 546nm to calculate the corresponding concentration of phenolic red. Through the expectorant experiment of phenol red in mice, the effects of dropping pill and pill on the secretion of phenol red in experimental mice respiratory tract were compared. |
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