| 肝巨噬细胞与肝纤维化研究进展 |
| 投稿时间：2022-09-12 修订日期：2023-10-22 点此下载全文 |
| 引用本文：江海燕,钟芳芳,张俊平.肝巨噬细胞与肝纤维化研究进展[J].药学实践杂志,2024,42(4):135~140 |
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| 中文摘要:肝纤维化是由各种病因所致慢性肝损伤的修复反应，其持续进展可发展为肝硬化甚至肝细胞癌，最终导致肝功能衰竭。目前，肝纤维化尚无有效治疗方法。肝巨噬细胞在肝内炎症反应、纤维化的进展和消退方面发挥关键作用，已成为抗肝纤维化的重要治疗靶细胞。主要就肝巨噬细胞在肝纤维化过程中的作用进行综述，以期能够为肝纤维化治疗提供思路。 |
| 中文关键词:肝巨噬细胞 肝纤维化 表型转换 |
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| Research progress on hepatic macrophages and liver fibrosis |
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| Abstract:Liver fibrosis is a repair response to chronic liver injury caused by various etiologies. Its continuous progression can develop into liver cirrhosis or even hepatocellular carcinoma, eventually leading to liver failure. Currently, there is no effective treatment for liver fibrosis. Hepatic macrophages play a key role in intrahepatic inflammatory response, progression and resolution of fibrosis, and have emerged as an important therapeutic target for anti-hepatic fibrosis. The function of hepatic macrophages in the process of liver fibrosis was mainly reviewed and the mode of action of hepatic macrophages from various aspects was discussed to provide ideas for the treatment of liver fibrosis. |
| keywords:hepatic macrophages liver fibrosis phenotypic switch |
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