| 黑蒜多糖抗便秘作用研究 |
| 投稿时间：2024-03-28 修订日期：2024-10-12 点此下载全文 |
| 引用本文：关梦瑶,夏天爽,何旭辉,史策,蒋益萍,辛海量.黑蒜多糖抗便秘作用研究[J].药学实践杂志,2025,43(4):190~194 |
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| 基金项目:海军军医大学药学系“雏鹰”学员培养计划-海军军医大学孵化基地项目（FH2024203） |
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| 中文摘要:目的 建立复方地芬诺酯诱导的小鼠功能性便秘（FC）模型，探究黑蒜多糖的抗便秘作用。方法 分别进行小鼠小肠墨汁推进实验以及小鼠排便实验研究。每个实验按照体重随机分为空白组、模型组、阳性组及黑蒜多糖低、中、高剂量组（0.25、0.5、1 g/kg），空白组、模型组小鼠给予蒸馏水，阳性组小鼠给予乳果糖口服液。预防给药1周后，5 mg/kg复方地芬诺酯（CO.D）混悬液灌胃造模，观察小鼠小肠墨汁推进率、首次排出黑便时间、6 h排便粒数、重量及含水量。结果 与模型组相比，黑蒜多糖低、中、高剂量组小鼠小肠墨汁推进率显著增加，首次排出黑便时间显著缩短，黑蒜多糖中、高剂量组小鼠6 h排便粒数及其重量、粪便含水量显著增大。结论 黑蒜多糖可显著促进复方地芬诺酯诱导的FC模型小鼠小肠蠕动，缩短排便时间，增加粪便含水量，从而发挥抗便秘作用。 |
| 中文关键词:黑蒜 多糖 抗便秘 |
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| Study on anti-constipation effect of black garlic polysaccharide |
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| Abstract:Objective To establish the functional constipated mouse model by compound diphenoxylate, and explore the anti-constipation effect of black garlic polysaccharide. Methods Mouse small intestine ink propulsion experiment and mouse defecation experiment were carried out respectively. The mice in each experiment were randomly divided into blank group, model group, positive group and black garlic polysaccharide （0.25, 0.5, 1 g/kg） groups. Mice in blank group and model group were given distilled water, and in positive group were given lactulose oral solution. Compound diphenoxylate （5 mg/kg） was intragastric administrated after 1 week of administration, and small intestine propulsion experiment and defecation experiment were conducted respectively. Results Compared with model group, intestinal propulsion rate of black garlic polysaccharide groups was significantly increased and first dejection time was significantly shorten, and the number, weight and fecal water content increased significantly at 6 h in middle and high dose groups. Conclusion Black garlic polysaccharide could promote intestinal propelling, shorten defecation time and increase fecal water content. |
| keywords:Black Garlic Polysaccharides Anti-constipation |
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