| 铁死亡调控蛋白GPX4的小分子抑制剂研究进展 |
| 投稿时间：2023-12-29 修订日期：2024-04-22 点此下载全文 |
| 引用本文：刘汝雄,杨万镇,涂杰,盛春泉.铁死亡调控蛋白GPX4的小分子抑制剂研究进展[J].药学实践杂志,2024,42(9):375~378 |
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| 中文摘要:铁死亡（ferroptosis）是2012年新发现的一种非凋亡坏死的细胞死亡方式，其主要特征为脂质活性氧增多以及细胞内亚铁离子累积。谷胱甘肽过氧化物酶4（GPX4）是含硒GPx家族第4位成员，是细胞清除脂质过氧化物的重要蛋白，也是铁死亡的重要调节因子。靶向GPX4小分子抑制剂能诱导铁死亡发生，为治疗耐药性癌症和神经退行性疾病提供了新的策略。主要介绍GPX4蛋白的结构和功能，并综述GPX4小分子抑制剂最新前沿进展，为开发基于GXP4抑制的铁死亡诱导剂提供研究基础。 |
| 中文关键词:GPX4 小分子抑制剂 铁死亡 谷胱甘肽 脂质过氧化 |
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| Research progress on small-molecule inhibitors of ferroptosis regulatory protein GPX4 |
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| Abstract:Ferroptosis, discovered in 2012, is a newly form of non-apoptotic and non-necrotic cell death, which is characterized by an increasement in lipid peroxidation and accumulation of intracellular iron ions. Glutathione peroxidase 4（GPX4）is the fourth member of the selenoprotein GPx family and plays a crucial role in clearing lipid peroxides in cells, making it an important regulator of ferroptosis. Small molecule inhibitors targeting GPX4 can induce ferroptosis, offering a new strategy for treating drug-resistant cancers and neurodegenerative diseases. The protein structure and function of GPX4 were primarily discusseed, and the latest advances in small molecule inhibitors of GPX4 were summarized, which provided a research foundation for developing ferroptosis inducers based on GPX4 inhibition. |
| keywords:ferroptosis GPX4 small molecule inhibitors glutathione lipid peroxidation |
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