| 一例消化道穿孔患者术后继发念珠菌血流感染的病例分析 |
| 投稿时间：2023-12-06 修订日期：2024-06-04 点此下载全文 |
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| 中文摘要:［］ 目的 探讨临床药师参与消化道穿孔患者术后继发念珠菌血流感染治疗的药物选择、用法用量及其效果,为此类抗感染治疗的临床用药方案提供参考。方法 在患者念珠菌感染治疗过程中,临床药师建议采用卡泊芬净替代氟康唑,以及修订卡泊芬净的用法用量和足疗程应用。结果 患者的念珠菌血流感染得到有效控制。结论 卡泊芬净等棘白菌素类为念珠菌感染首选药物,卡泊芬净在中毒肝功能损伤时将维持剂量降至每天35mg为宜,同时抗感染治疗应至血培养转阴后至少14 天。临床药师参与临床查房等药学服务实践,主动协助医生制定个体化抗感染方案,可提升临床药物使用水平,改善疾病的临床结局。 |
| 中文关键词:［］ 卡泊芬净 念珠菌感染 氟康唑 |
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| A case of postoperative candida bloodstream infection occurred in patients with digestive tract perforation |
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| Abstract:Objective To explore the drug selection, usage, dosage and effect of clinical pharmacists in the treatment of secondary Candida bloodstream infection in patients with digestive tract perforation, and to provide reference for the clinical drug use scheme of such anti-infection treatment. Methods During the treatment of Candida infection in patients, clinical pharmacists recommend the replacement of fluconazole, and revise the dosage and full course of caspofungin. Results The patient"s Candida bloodstream infection was effectively controlled. Conclusion Echininocandins such as caspofungin are the first choice for Candida infection. The maintenance dose should be reduced to 35mg qd in toxic liver function injury, and the anti-infection treatment should be at least 14 days after the transformation of blood culture is negative. Clinical pharmacists participate in clinical pharmaceutical care practices such as clinical ward rounds, and actively assist doctors to develop individualized anti-infection programs, which can improve the level of clinical drug use and improve the clinical outcome of diseases. |
| keywords:caspofungin Candida infection fluconazole |
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