| 以抗炎为潜在靶点的治疗糖尿病肾病的新药研究进展 |
| 投稿时间：2021-09-13 修订日期：2022-04-20 点此下载全文 |
| 引用本文：史小飞,陈弋,向科发,张慧敏,高越,刘霞.以抗炎为潜在靶点的治疗糖尿病肾病的新药研究进展[J].药学实践杂志,2023,41(10):581~585,628 |
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| 中文摘要:糖尿病肾病（DN）是1型糖尿病（T1DM）和2型糖尿病（T2DM）常见的微血管并发症，也是慢性肾病(CKD)和终末期肾病（ESRD）的主要原因，但目前治疗手段有限。越来越多的证据表明，炎症反应参与了DN的发病和进展。针对特定炎症介质（转录因子、促炎性细胞因子、趋化因子、黏附分子）和细胞内信号通路的几种抗炎策略在DN模型中显示出其是一个有利因素，重点综述炎症在DN发生和进展中的相关机制，并简单讨论基于炎症来预防或治疗DN的新策略。 |
| 中文关键词:糖尿病肾病 炎症 治疗 |
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| Research progress on innovative drugs for diabetic nephropathy with potential anti-inflammatory targets |
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| Abstract:Diabetic nephropathy (DN) is a common microvascular complication of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM)，which is also the main cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD). However, the treatment methods are limited at present. More and more evidences have indicated that inflammatory response is involved in the pathogenesis and progression of DN. Several anti-inflammatory strategies that target specific inflammatory mediators (transcription factors, pro-inflammatory cytokines, chemokines, adhesion molecules) and intracellular signaling pathways have shown benefits in the DN rodent model. The mechanisms related to inflammation in the development and progression of DN were summarized and new strategies to prevent or treat DN based on inflammation were briefly discussed in this review. |
| keywords:diabetic nephropathy inflammation treatment |
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