| 低蛋白血症对头孢哌酮血药浓度的影响 |
| 投稿时间：2023-09-18 修订日期：2024-01-29 点此下载全文 |
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| 基金项目:湖南省医学会临床药学科研基因项目（HMA202001014） |
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| 中文摘要:目的：分析低蛋白血症对患者使用头孢哌酮的影响，为临床合理使用头孢哌酮提供依据。方法：采用回顾性分析法，收集 2021 年 7 月至 2022 年 3 月期间使用头孢哌酮舒巴坦治疗并进行头孢哌酮血药浓度监测的患者，根据患者白蛋白浓度不同，将患者分为低蛋白组和白蛋白正常组，对两组患者性别、年龄、实验室检查、头孢哌酮谷浓度和临床疗效等进行统计分析。结果：两组患者年龄、性别、炎症指标及肝功能均无统计学差异（P＞0.05）。低蛋白组患者肌酐显著高于白蛋白正常组患者（P＜0.05）。低蛋白组头孢哌酮谷浓度为 46.29±36.94 mg/L，白蛋白正常组头孢哌酮谷浓度为 38.18±33.79 mg/L ，其中低蛋白组使用人血白蛋白的患者头孢哌酮血药浓度显著高于未使用人血白蛋白的患者（P＜0.05）。两组临床疗效相比，低蛋白组患者临床治疗有效率偏低（P＜0.05）。结论：低蛋白血症患者补充人血白蛋白可以提高头孢哌酮的血药浓度，通过纠正患者低蛋白血症有助于提高头孢哌酮舒巴坦抗感染的临床疗效。 |
| 中文关键词:头孢哌酮 低蛋白血症 临床疗效 |
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| Effect of Hypoproteinemia on Cefoperazone Plasma Concentration |
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| Abstract:[Abstract] Objective To analyze the effect of hypoproteinemia on the use of cefoperazone sulbactam in patients, and to provide basis for the rational use of cefoperazone in clinical practice. Methods Clinical data of patients with cefoperazone blood concentration monitoring in our hospital form July 2021 to March 2022 were collected, and divided into low albumin group and normal albumin group according to different albumin concentration. Statistical analysis were conducted based on gender, age, laboratory examination, cefoperazone valley concentration and clinical efficacy of the two groups . Results Two groups of patients’ age, gender, inflammation and liver function have not statistical difference (P＞0.05). Low protein group had significantly higher levels of creatinine than those in patients with normal albumin (P<0.05). The trough concentration of cefoperazone in the low protein group was 46.29 ± 36.94 mg/L, and that in the normal albumin group was 38.18 ± 33.79 mg/L. Among the low protein patient group, the plasma concentration of cefoperazone in those treated with human album was significantly higher than that in the patients without human albumin treatment (P<0.05). Comparison of the clinical efficacy of the two groups revealed that the low protein group had a lower clinical response rate (P<0.05). Conclusion Supplementation of human serum albumin in patients with hypoproteinemia can increase the plasma concentration of cefoperazone, and correcting hypoproteinemia is helpful for anti-infection treatment. |
| keywords:Cefoperazone Hypoproteinemia Clinical efficacy |
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