乳酸菌作为重组蛋白药物递送载体的研究
投稿时间:2023-09-12  修订日期:2023-11-30  点此下载全文
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作者单位邮编
王旭昉 海军军医大学药学系 200433
王彦婷 海军军医大学药学系 200433
姚春萌 海军军医大学药学系 200433
陆斌 海军军医大学药学系 200433
中文摘要:乳酸菌基于其安全性、益生性及肠道可定植性,是活体药物递送系统的良好候选者,现阶段众多研究将其作为蛋白药物递送载体用于疾病治疗。作为一种模式生物,多样化的基因修饰方案使其可以应用于各类疾病并能够发挥显著的治疗效果。乳酸菌药物载体具有多种优势,包括无创给药、基因可编辑性、可大规模生产等,因此利用乳酸菌作为重组蛋白表达载体的研究引起了全球范围的关注。本文对乳酸菌药物递送系统的应用基础、生物利用度提升、基因编辑策略以及研究应用现状进行了归纳和总结。
中文关键词:乳酸菌  生物药物  递送载体
 
Lactic acid bacteria as recombinant protein drug delivery vector
Abstract:Lactic acid bacteria is a good candidate in living drug delivery system for its safety, beneficial nature, and intestinal colonizability. At present, most studies use it as a protein drug delivery vehicle for disease treatment. As a model organism, a variety of gene modification schemes enable it to be applied to various diseases and can play a significant therapeutic effect. Lactic acid bacteria drug carrier has many advantages, including non-invasive drug delivery, gene editing, large-scale production, so the use of lactic acid bacteria as recombinant protein expression vector has attracted global attention. In this review, the application basis, bioavailability improvement, gene editing strategy and research and application status of lactobacillus drug delivery system were summarized.
keywords:lactic acid bacteria  biological drug  delivery vector
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