| 气相色谱法测定清肠栓中樟脑残留量和冰片含量 |
| 投稿时间：2022-08-31 修订日期：2023-03-15 点此下载全文 |
| 引用本文：潘宇炯,何志高,周昕,章恒周,杨月红,黄景山.气相色谱法测定清肠栓中樟脑残留量和冰片含量[J].药学实践杂志,2023,41(9):552~556 |
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| 基金项目:上海市进一步加快中医药传承创新发展三年行动 计划（ZY(2021-2023)-0203-01） |
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| 中文摘要:目的 建立清肠栓中樟脑残留物和冰片含量的气相测定方法。方法 采用气相色谱法，色谱柱为Agilent毛细管柱（30 m×0.25 mm×0.25 μm），柱温为140 ℃，进样口温度250 ℃，检测器（FID）温度为250 ℃。结果 樟脑、龙脑和异龙脑在0.0299~1.497μg（r=1.000）、0.0205~1.025μg（r=1.000）、0.0097~0.4830 μg（r=1.000）范围内呈现良好的线性关系。精密度、稳定性、重复性试验结果的RSD均小于2%，平均加样回收率分别为99.7%、101.0%、102.5%。结论 该方法准确、可靠、简便快速，可用于清肠栓中龙脑含量的测定。 |
| 中文关键词:气相色谱法 清肠栓 樟脑 龙脑 异龙脑 含量测定 |
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| Determination of camphor residue and borneol content in Qingchang Suppository by GC |
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| Abstract:Objective To establish a gas chromatography for simultaneous determination of camphor residue and borneolum content in Qingchang Suppository. Methods Gas chromatograph method was used. The chromatographic column was Agilent capillary column(30 m×0.25 mm×0.25 μm). The column temperature was 140 ℃. The sample injection temperature was 250 ℃. The FID detector temperature was 250 ℃. Results Camphor，borneol and isoborneol content showed good linear in the extent of 0.0299~1.497(r=1.000), 0.0205~1.025(r=1.000), 0.0097~0.4830 μg (r=1.000). RSDs of precision，stability and repeatability test results were less than 2%. The recovery was 99.7%, 101.0%, 102.5%. Conclusion This method is simple and quick with accurate result, which could be used for the content determination of Borneol in Qingchang Suppository. |
| keywords:GC Qingchang Suppository Camphor Borneol Isoborneol Content determination |
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