| 线性泛素连接酶复合体与去线性泛素化酶在肿瘤中的研究进展 |
| 投稿时间：2023-07-21 修订日期：2023-08-15 点此下载全文 |
| 引用本文：方宇昕,李育,刘宝姝,董国强.线性泛素连接酶复合体与去线性泛素化酶在肿瘤中的研究进展[J].药学实践杂志,2023,41(9):534~539 |
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| 中文摘要:线性泛素化修饰是近年来发现的一种重要的翻译后修饰。线性泛素链由一分子泛素的甘氨酸与另一分子泛素的甲硫氨酸连接而形成。线性泛素化修饰过程由线性泛素连接酶复合体（LUBAC）与去线性泛素化酶（OTULIN）共同调控，广泛参与机体免疫、炎症反应、细胞凋亡等过程。近年来的研究表明，线性泛素化修饰能够影响NF-κB、Wnt/β-catenin等信号通路，并与肿瘤的发生、发展和耐药密切相关。本文将对LUBAC与OTULIN在肿瘤中的研究进展进行综述。 |
| 中文关键词:线性泛素化修饰 线性泛素连接酶复合体 去线性泛素化酶 肿瘤 |
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| Research Progress on Linear Ubiquitin Chain Assembly Complex and OTU Deubiquitinase With Linear Linkage Specificity in Tumor |
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| Abstract:Linear ubiquitination is an important post-translational modification that has been discovered in recent years. The linear ubiquitin chain is formed by the linkage of glycine residue of one ubiquitin protein to the methionine residue of another ubiquitin. This process is regulated by the linear ubiquitin chain assembly complex (LUBAC) and the OTU deubiquitinase with linear linkage specificity (OTULIN). Linear ubiquitination is involved in various biological processes, including immune response, inflammation, and cell apoptosis. Recent studies have shown that linear ubiquitination is closely related to the occurrence, development, and drug resistance of tumors by affecting signaling pathways such as NF-κB and Wnt/β-catenin. The research progress on the function of LUBAC and OTULIN in tumors was reviewed in this paper. |
| keywords:Linear ubiquitination Linear ubiquitin chain assembly complex OTU deubiquitinase with linear linkage specificity Tumor |
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