康复新液联合利多卡因及庆大霉素治疗口腔溃疡的临床疗效观察
投稿时间:2022-07-21  修订日期:2022-10-27  点此下载全文
引用本文:赵玲,吴亚楠,徐名媛.康复新液联合利多卡因及庆大霉素治疗口腔溃疡的临床疗效观察[J].药学实践杂志,2023,41(8):515~518
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作者单位
赵玲 北京市通州区妇幼保健院口腔科北京 101101 
吴亚楠 北京市通州区妇幼保健院口腔科北京 101101 
徐名媛 北京市通州区妇幼保健院口腔科北京 101101 
中文摘要:目的 探讨康复新液联合利多卡因及庆大霉素治疗口腔溃疡的临床疗效。方法 选取2019年5月至2021年7月在北京市通州区妇幼保健院收治的120例口腔溃疡患者,按照随机表法分为观察组和对照组,对照组58例采用利多卡因治疗,观察组62例采用康复新液联合利多卡因及庆大霉素治疗,观察对比两组治疗前后的临床疗效,包括口腔溃疡情况、治疗3 d、治疗5 d后视觉模拟评分(VAS评分)、炎症因子水平及不良反应等。结果 治疗后观察组总有效率(95.12%)高于对照组总有效率(74.36%),差异有统计学意义(P<0.05);溃疡面积、溃疡愈合时间、进食改善时间显著短于对照组(P<0.05);观察组治疗3 d、5 d后VAS评分、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、细胞白介素-6(IL-6)水平均较对照组显著降低(P<0.05);观察组不良反应发生率(3.22%)与对照组不良反应发生率(6.90%)相比,差异无统计学意义(P>0.05)。结论 康复新液联合利多卡因及庆大霉素治疗口腔溃疡的疗效更好,能有效改善患者各项临床症状,降低患者疼痛感,降低炎症因子水平,有助于患者恢复,并且安全性高。
中文关键词:炎症因子  康复新液  利多卡因  庆大霉素  口腔溃疡
 
Clinical effect of Kangfuxin solution combined with lidocaine and gentamicin in the treatment of oral ulcer
Abstract:Objective To investigate the clinical efficacy of Kangfuxin solution combined with lidocaine and gentamicin in the treatment of oral ulcers. Method A total of 120 patients with oral ulcer admitted to Tongzhou District Maternity and Child Health Care Hospital of Beijing from May 2019 to July 2021 were selected and divided into observation group and control group randomly. 58 patients were treated with lidocaine as a control group and 62 patients in the observation group were treated with Kangfuxin solution combined with lidocaine and gentamicin. The clinical efficacy, including oral ulcer condition, visual analogue scale (VAS score) after 3d and 5d of treatment, inflammatory factor levels and adverse reactions were observed and compared between the two groups before and after treatment. Results The overall effective rate of the treatment group (95.12%) was higher than that of the control group (74.36%) and the difference was statistically significant (P<0.05). The ulcer area, ulcer healing time, and chewing improvement period were remarkably reduced compared with those in the control group (P<0.05). The VAS scores after 3d and 5d of treatment, the levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6) between the two groups were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions (3.22%) between the observation group and the control group (6.90%) (P>0.05). Conclusion Kangfuxin solution combined with lidocaine and gentamicin showed better curative effect on oral ulcer. This treatment regimen could effectively ameliorate various clinical symptoms of patients with oral ulcer, reduce patient pain and downregulate the levels of inflammatory factors, and help patients recover with high safety profile.
keywords:Inflammatory factor  Kangfuxin solution  Lidocaine  Gentamicin  Oral ulcer
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