| 补骨脂二氢黄酮甲醚的药理活性及肝毒性研究进展 |
| 投稿时间：2022-04-08 修订日期：2022-08-23 点此下载全文 |
| 引用本文：周容睿,魏艳平,陈威,丁倩倩,王金鑫,祖先鹏.补骨脂二氢黄酮甲醚的药理活性及肝毒性研究进展[J].药学实践杂志,2023,41(8):465~471 |
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| 中文摘要:补骨脂二氢黄酮甲醚是来源于豆科补骨脂属植物补骨脂Psoralea corylifolia L.干燥成熟果实的二氢黄酮类成分，具有抗肿瘤、抗病毒、抗糖尿病、抗炎及神经保护等药理活性，有着良好的临床应用潜力。随着临床上对补骨脂用药安全的不断关注，补骨脂二氢黄酮甲醚已被证实会造成肝细胞损伤。本文综述了近20年来关于补骨脂二氢黄酮甲醚的药理活性及肝毒性研究概况，为补骨脂二氢黄酮甲醚的后续研究和临床应用提供参考。 |
| 中文关键词:补骨脂二氢黄酮甲醚 药理作用 抗肿瘤 抗病毒 抗糖尿病 神经保护 抗炎 肝毒性 |
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| Progress on pharmacological activities and hepatotoxicity of bavachinin |
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| Abstract:Bavachinin is a dihydroflavone isolated from dried ripe fruits of Psoralea corylifolia L.，which has various pharmacological activities, such as anti-tumor, anti-virus, anti-diabetes, anti-inflammatory and neuroprotective, and good potential in clinical applications. With the increasing concern about the safety of P. corylifolia applications in clinical, the bavachinin has been found to be one of the main components causing liver injury. In this paper, the pharmacological activities and hepatotoxicity of bavachinin in the recent 20 years were reviewed, in order to provide reference for the further study and clinical application. |
| keywords:bavachinin pharmacological activity anti-tumor anti-virus anti-diabetes neuroprotective anti-inflammatory liver toxicity |
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