| MT-1207对小鼠血糖、血脂和动脉粥样硬化的作用 |
| 投稿时间：2023-06-07 修订日期：2024-01-23 点此下载全文 |
| 引用本文：张修平,田家盛,王道鑫,李佳鑫,王品,缪朝玉.MT-1207对小鼠血糖、血脂和动脉粥样硬化的作用[J].药学实践杂志,2024,42(11):487~494 |
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| 中文摘要:目的 研究MT-1207对小鼠血糖、血脂和动脉粥样硬化的作用。方法 载脂蛋白E (ApoE)基因敲除(ApoE-/-)小鼠分别给予普通饲料、氯沙坦含药饲料和MT-1207含药饲料，给药剂量为30 mg/kg，测定小鼠的体质量、血糖和血脂指标，并评价动脉粥样硬化的斑块面积。对8周龄的雄性C57小鼠给予高脂饲料，每天以30 mg/kg的剂量灌胃MT-1207和氯沙坦，考察小鼠的体质量、血糖和血脂的水平，进一步评价MT-1207对血糖、血脂的作用。 结果 长期MT-1207饲料给药和氯沙坦饲料给药的ApoE-/-小鼠体质量增长更快，但血糖和血脂的水平没有显著改善，动脉粥样硬化的斑块面积也无明显变化。MT-1207和氯沙坦对高脂饮食的C57小鼠血糖、血脂均无明显改善作用。结论 MT-1207和氯沙坦对血糖、血脂以及动脉粥样硬化没有改善作用，不会加重动脉粥样硬化。 |
| 中文关键词:MT-1207 氯沙坦 动脉粥样硬化 血糖 血脂 |
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| Effects of MT-1207 on blood glucose, blood lipids and atherosclerosis in mice |
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| Abstract:Objective To study the effect of MT-1207 on blood glucose, blood lipids and atherosclerosis in mice. Methods The apolipoprotein E knockout (ApoE-/-) mice were fed with normal feed, drug feed containing losartan and drug feed containing MT-1207 at a dosage of 30 mg/kg. The body weight, blood glucose and blood lipids were detected, and the plaque area of atherosclerotic was evaluated. 8-week-old male C57 mice were fed a high fat diet and given intragastric administration of MT-1207 and losartan at a dose of 30 mg/kg per day. The body weight, blood glucose and lipids levels were also examined to further evaluate the effects of MT-1207 on blood glucose and lipids levels. Results ApoE-/- mice treated with MT-1207 and losartan gained weight faster. There was no significant improvement in blood glucose and lipid levels, and no significant change in atherosclerotic plaque area. MT-1207 and losartan had no significant improvement effect on blood glucose and blood lipids of C57 mice. Conclusion MT-1207 and losartan couldn’t improve the levels of blood glucose, blood lipids and atherosclerosis, and couldn’t aggravate atherosclerosis. |
| keywords:MT-1207 losartan atherosclerosis blood glucose blood lipids |
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