| 血管内皮细胞线粒体氧化应激与动脉粥样硬化 |
| 投稿时间：2022-05-31 修订日期：2022-09-15 点此下载全文 |
| 引用本文：王道鑫,张添光,缪朝玉.血管内皮细胞线粒体氧化应激与动脉粥样硬化[J].药学实践杂志,2023,41(6):329~334,392 |
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| 基金项目:国家自然科学基金重点项目（81730098，82030110） |
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| 中文摘要:血管内皮细胞损伤是动脉粥样硬化病理过程的起始环节。线粒体氧化应激与血管内皮细胞功能密切相关，线粒体氧化应激通过诱导线粒体自噬、一氧化氮生成减少、炎症反应、细胞代谢失衡和凋亡，导致血管内皮细胞的功能障碍。同时，血管内皮细胞也通过调控线粒体氧化应激维持自身稳态。本文旨在综述动脉粥样硬化病理过程中线粒体氧化应激诱发血管内皮细胞损伤的主要分子信号通路，为后续研究两者间的分子机制提供参考。 |
| 中文关键词:线粒体氧化应激 内皮细胞 动脉粥样硬化 作用机制 |
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| Mitochondrial oxidative stress in vascular endothelial cell and atherosclerosis |
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| Abstract:The injury of vascular endothelial cell function is the beginning of the pathological process of atherosclerosis. Mitochondrial oxidative stress is closely related to vascular endothelial cell function, which causes the dysfunction of vascular endothelial cell by inducing mitophagy, reducing nitric oxide production, inflammation, cellular metabolic imbalance and apoptosis. Meanwhile, vascular endothelial cell could also maintain their homeostasis by regulating mitochondrial oxidative stress. The molecular signaling pathways of the vascular endothelial cell injury caused by mitochondrial oxidative stress in the pathological process of atherosclerosis were outlined in this review, which provided reference for further research on the molecular mechanism between mitochondrial oxidative stress and endothelial damage. |
| keywords:mitochondrial oxidative stress endothelial cell atherosclerosis mechanisms of action |
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