| 基于网络药理学探讨麝香保心丸治疗动脉粥样硬化作用机制 |
| 投稿时间：2021-12-01 修订日期：2022-09-07 点此下载全文 |
| 引用本文：王智聪,谢彬,袁星,徐希科,柳润辉.基于网络药理学探讨麝香保心丸治疗动脉粥样硬化作用机制[J].药学实践杂志,2023,41(5):296~301 |
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| 基金项目:国家自然科学基金项目（82073981） |
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| 中文摘要:目的 研究麝香保心丸治疗动脉粥样硬化的作用机制，为临床长期应用提供理论依据。方法 利用TCMSP、TCMID、ETCM和BATMAN数据库对麝香保心丸有效成分及靶点进行收集与筛选；利用GeneCards、OMIM、TCMSP、DrugBank和DisGeNet对动脉粥样硬化相关靶点进行收集与筛选；构建药物-化合物-靶点网络和靶点相互作用网络；通过MetaScape平台对麝香保心丸治疗动脉粥样硬化相关靶点进行GO和KEGG富集分析。结果 筛选出麝香保心丸对动脉粥样硬化潜在治疗成分114个，对应175个靶点。网络分析结果表明，麝香保心丸主要活性成分为鹅去氧胆酸、熊去氧胆酸、肉桂醛和人参皂苷Rb1等入血成分。通路富集结果显示，麝香保心丸抗动脉粥样硬化的作用机制与调节免疫、炎症和代谢相关。结论 麝香保心丸的活性成分可作用于ALB、INS、AKT1、ACTB、TNF、IL-6等靶点，调节多条通路实现对动脉粥样硬化的治疗作用。 |
| 中文关键词:麝香保心丸 网络药理学 动脉粥样硬化 作用机制 |
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| Mechanism of Shexiang Baoxin pill in the treatment of atherosclerosis based on network pharmacology |
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| Abstract:Objective To study the mechanism of Shexiang Baoxin pill in the treatment of atherosclerosis, and to provide a theoretical basis for long-term clinical application. Methods The chemical components and targets of Shexiang Baoxin pill were collected and screened by TCMSP, TCMID, ETCM and BATMAN databases. The targets related to atherosclerosis were collected and screened by DisGeNet, OMIM, TCMSP, DrugBank and DisGeNet. Drug-compound target network and protein-protein interaction network were constructed. Go and KEGG enrichment analysis of Shexiang Baoxin pill in the treatment of atherosclerosis were carried out on MetaScape platform. Results 114 potential therapeutic components of Shexiang Baoxin pill on atherosclerosis were selected, corresponding to 175 targets. The results of network analysis showed that the main active components of Shexiang Baoxin pill were chenodeoxycholic acid, ursodeoxycholic acid, cinnamaldehyde and ginsenoside Rb1. The results of pathway enrichment showed that the anti-atherosclerotic mechanism of Shexiang Baoxin pill was related to the regulation of immunity, inflammation, and metabolism. Conclusion The active components of Shexiang Baoxin pill could act on ALB, INS, AKT1, ACTB, TNF, IL-6 and other targets, regulating multiple pathways to achieve the therapeutic effect on atherosclerosis. |
| keywords:Shexiang Baoxin pill network pharmacology atherosclerosis mechanism |
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