| 细胞膜仿生纳米载体的制备及应用研究进展 |
| 投稿时间：2022-02-21 修订日期：2022-04-12 点此下载全文 |
| 引用本文：代宇,王宏播,卞康晴,郭灵怡,俞媛.细胞膜仿生纳米载体的制备及应用研究进展[J].药学实践杂志,2023,41(3):135~138,145 |
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| 基金项目:国家自然科学基金 (82273487)；全军医学科技青年培育计划（21QNPY051） |
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| 中文摘要:由有机或无机纳米材料制备的药物载体系统广泛用于药物靶向递送和疾病的诊断治疗研究。但其存在靶向性差、体内循环时间短、生物相容性欠佳亟需提高等问题。仿生纳米药物系统是以不同种类的细胞膜修饰纳米载体，利用内源性的细胞膜提高载体的体内生物相容性、实现更精准的靶向、甚至由细胞自身的免疫原性产生免疫治疗作用。对细胞膜仿生纳米载体技术的原理、方法及其靶向机制和治疗作用作一综述，为新型给药系统研究提供思路。 |
| 中文关键词:细胞膜 仿生纳米载体 药物递送系统 生物材料 |
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| Progress in preparation and application of biomimetic nano carriers for cell membrane |
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| Abstract:Nanocarriers prepared from organic or inorganic materials are widely used in drug targeting system and diagnosis and treatment of disease. However, there are some problems, such as poor targeting, short circulation time in vivo and improvement in the biocompatibility. Biomimetic nanocarriers has carried out research on the issues, which based on different kinds of cell membrane for the nanocarriers modification, endogenous biofilm improving the biocompatibility of carriers in vivo, more accurate targeting, and even producing immunotherapeutic effect. The principle, method, targeting mechanism and therapeutic effect of biomimetic nano carrier technology of cell membrane have been reviewed in this paper, which provide a new direction for the research of new drug delivery system. |
| keywords:cell membrane biomimetic nanocarriers drug delivery system biomaterials |
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