| 基于网络药理学对舒肝宁注射液抗炎保肝作用的机制研究 |
| 投稿时间：2022-04-11 修订日期：2022-07-10 点此下载全文 |
| 引用本文：辛宝,解方园,姚晨,葛继芸,刘静,张菁,缪宏,黄婷婷,黄玉凤.基于网络药理学对舒肝宁注射液抗炎保肝作用的机制研究[J].药学实践杂志,2022,40(6):563~570 |
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| 中文摘要:目的 构建舒肝宁注射液活性成分-作用靶点和蛋白相互作用网络，探讨舒肝宁注射液抗炎保肝作用机制。方法 通过TCMSP数据库获取舒肝宁注射液中茵陈、栀子、黄芩、板蓝根和灵芝的主要活性成分；利用GeneCard和OMIM数据库筛选舒肝宁注射液活性成分对应靶点中与肝炎相关靶点；采用Cytoscape构建活性成分-作用靶点网络；应用String数据库和Cytoscape软件绘制蛋白相互作用网络；通过DAVID数据库对靶点进行GO及KEGG通路分析。结果 筛选得到舒肝宁注射液活性成分20个，共83个作用靶点。GO分析表明，舒肝宁注射液主要影响细胞过程和生物过程的调控，以及对化学刺激和应激的反应等作用。KEGG通路分析显示，舒肝宁注射液抗炎保肝作用的靶点主要涉及TNF、IL-17、MAPK等信号通路。结论 舒肝宁注射液的抗炎保肝作用具有多成分、多靶点、多通路的特点，可能通过调节TNF、IL-17、MAPK等通路发挥作用。 |
| 中文关键词:舒肝宁注射液 抗炎作用 网络药理学 分子机制 |
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| Study on the mechanism of anti-inflammatory and hepatoprotective effects of Shuganning injection based on network pharmacology |
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| Abstract:Objective To explore the anti-inflammatory and hepatoprotective mechanism of Shuganning injection through establishing the active ingredients-targets network and protein interactions network. Methods The main active ingredients of Artemisiae scopariae, Fructus gardenia, Radix scutellariae, Radix isatidis and Ganoderma in Shuganning injection were obtained by TCMSP; GeneCards and OMIM were used to screen the hepatitis-related targets among the corresponding targets of the active ingredient of Shuganning injection; The Cytoscape software was used to construct the active ingredient-targets network of Shuganning injection. The protein interactions network was constructed using the String database and Cytoscape software. The GO and KEGG pathways involved in the targets were analyzed by DAVID database. Results The results showed that 20 active ingredients and 83 targets of Shuganning injection were involved. GO analysis showed that Shuganning injection mainly affected the regulation of cellular processes and biological processes, as well as the response to chemical stimulation and stress. KEGG pathway analysis showed that the targets of the anti-inflammatory and hepatoprotective effect of Shuganning injection mainly involved in signaling pathways such as TNF, IL-17, and MAPK. Conclusion The anti-inflammatory and hepatoprotective effect of Shuganning injection have the characteristics of multiple components, multiple targets and multiple pathways, which may play a role by regulating pathways such as TNF、IL-17 and MAPK . |
| keywords:Shuganning injection anti-inflammatory effect network pharmacology molecular mechanism |
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