| 极地海绵共附生放线菌Streptomyces sp. LHW11-07次生代谢产物研究 |
| 投稿时间：2022-06-18 修订日期：2022-07-16 点此下载全文 |
| 引用本文：卢静容,刘雅葳,代影,林厚文,杨帆.极地海绵共附生放线菌Streptomyces sp. LHW11-07次生代谢产物研究[J].药学实践杂志,2022,40(6):499~504 |
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| 基金项目:国家自然科学基金项目（82073758） |
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| 中文摘要:目的 对极地海绵共附生放线菌Streptomyces sp. LHW11-07进行次生代谢产物的研究，以期得到结构新颖且具有良好生物活性的小分子化合物。方法 综合运用凝胶柱色谱、硅胶柱色谱、反相中压柱色谱和高效液相色谱等分离手段对Streptomyces sp. LHW11-07发酵产物进行分离和纯化，采用质谱、一维、二维核磁共振等现代波谱方法并结合相关文献调研鉴定它们的结构。结果 从该菌的发酵产物中共分离得到9个单体化合物，分别为cyclo-(L-Tyr-L-Trp) (1)、cyclo-(L-Trp-L-Ser) (2)、cyclo-(D-Tyr-D-Pro) (3)、cyclo-(L-Tyr-L-Phe) (4)、cyclo-(L-Tyr-L-Leu) (5)、albaflavenol B (6)、β-adenosine (7)、N-formylantimyic acid methyl ester (8)和conglobatin A (9)。结论 化合物1和2是首次分离于Streptomyces属放线菌。 |
| 中文关键词:极地 海绵 放线菌 次生代谢产物 |
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| Study on the secondary metabolites from a polar marine sponge associated actinomyces Streptomyces sp. LHW11-07 |
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| Abstract:Objective In order to obtain small molecule compounds with novel structure and good biological activity, the secondary metabolites of polar sponge-symbiotic Streptomyces sp. LHW11-07 were studied. Methods The fermentation product of Streptomyces sp. LHW11-07 was isolated and purified by gel column chromatography, silica gel column chromatography, reversed-phase medium pressure column chromatography and high performance liquid chromatography. The structures of the monomeric compound were identified by modern spectroscopic methods such as mass spectrometry, nuclear magnetic resonance and related literature reports. Results A total of nine compounds were isolated from the fermentation of this strain, which were cyclo-(L-Tyr-L-Trp) (1), cyclo-(L-Trp-L-Ser) (2), cyclo-(D-Tyr-D-Pro) (3), cyclo-(L-Tyr-L-Phe) (4), cyclo-(L-Tyr-L-Leu) (5), albaflavenol B (6), β-adenosine (7), N-formylantimyic acid methyl ester (8) and conglobatin A (9). Conclusion Compounds 1 and 2 were isolated from Streptomyces sp. for the first time. |
| keywords:polar region sponge actinomyces secondary metabolite |
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