| 基于数据挖掘的中医药促进创面修复用药规律的研究 |
| 投稿时间：2021-04-21 修订日期：2021-06-08 点此下载全文 |
| 引用本文：雷忠卫,杜揭,孙宏艺,顾秦五风,李柏,杨延龙.基于数据挖掘的中医药促进创面修复用药规律的研究[J].药学实践杂志,2022,40(3):281~285 |
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| 基金项目:海军军医大学第一附属医院“深蓝123”军事医学研究专项 自由探索项目（2019SLZ003）；上海市2020年度“科技创新行动计划”医学创新研究专项（20Y21900900）；海军军医大学本科生创新孵化基地项目（FH2018154） |
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| 中文摘要:目的 通过整理、挖掘古代典籍和现代文献中促进创面修复的用药规律，为促进修复的临床用药提供新思路。方法 收集文献中记载的促进创面修复方剂，建立数据库，采用数据挖掘技术进行分析。结果 在关于中医药促进创面修复的古籍文献中，纳入75首方剂和203味中药，促进创面修复的核心药物有乳香、甘草、当归、白芷、黄柏、没药等，用药种类以清热药、活血化瘀药、补虚药、解表药、拔毒化腐生肌药为主。对16味核心药物进行聚类分析和关联规则分析，得出4个聚类组合和15组药对及药组关联规则。结论 创面修复方剂的用药规律以清热、活血化瘀、补虚、解表、拔毒化腐生肌为主，中医治疗创面应针对热病、血瘀、虚证、腐烂溃破、表证、中毒等因素进行辨证论治。 |
| 中文关键词:数据挖掘 中医药 创面修复 用药规律 |
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| Study on the rules of traditional Chinese medicine to promote wound healing based on data mining |
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| Abstract:Objective To provide new ideas for promoting wound healing by digging and sorting out the medication rules in ancient classics and modern literatures. Methods The prescriptions for promoting wound healing recorded in literatures were collected to establish the database. The data mining technology was used for the analysis. Results 75 prescriptions and 203 traditional Chinese medicines were recorded in the ancient TCM literatures for promoting wound healing. The core medicines included frankincense, liquorice, angelica sinensis, angelica dahuricae, cortex phellodendri, myrrh, etc. They mainly belong to the class of clearing-heat drugs, promoting-circulation drugs, reinforcing drugs, relieving drugs, detoxification and tissue granulation drugs. Cluster analysis and association rule analysis were conducted for 16 core drugs. 4 cluster combinations ,15 groups of drug pairs and drug group association rules were obtained. Conclusion The prescription rules for wound healing mainly included clearing heat, promoting circulation, reinforcing, relieving, detoxification, and promoting tissue granulation. TCM wound treatment should be based on syndrome differentiation for fever, blood stasis, deficiency, anabrosis, exterior syndrome and poisoning. |
| keywords:data mining traditional Chinese medicine wound healing medication rule |
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