| 盐酸苯海拉明/咖啡因复方的安全药理学研究 |
| 投稿时间：2021-05-25 修订日期：2021-07-14 点此下载全文 |
| 引用本文：任丽君,顾静,侍雯婧,王瑞娜,张晓芳,陈基快.盐酸苯海拉明/咖啡因复方的安全药理学研究[J].药学实践杂志,2022,40(3):238~242,285 |
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| 作者 | 单位 | E-mail | | 任丽君 | 海军军医大学海军医学系卫生毒理学教研室, 上海, 200433 | | | 顾静 | 海军军医大学海军医学系卫生毒理学教研室, 上海, 200433 | | | 侍雯婧 | 海军军医大学海军医学系卫生毒理学教研室, 上海, 200433 | | | 王瑞娜 | 海军军医大学药学系军特药研究中心, 上海, 200433 | | | 张晓芳 | 海军军医大学海军医学系卫生毒理学教研室, 上海, 200433 | | | 陈基快 | 海军军医大学海军医学系卫生毒理学教研室, 上海, 200433 | cjk.smmu@hotmail.com |
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| 基金项目:国家重点研发计划(2019YFC0312604)；“海狼”军事医学青年人才培育课题(HL20JD2511) |
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| 中文摘要:目的 观察盐酸苯海拉明/咖啡因复方对小鼠神经系统及Beagle犬心血管系统、呼吸系统的影响，为临床安全用药提供参考。方法 观察盐酸苯海拉明/咖啡因复方单次灌胃给药对小鼠爬杆能力的影响，以及对Beagle犬血压、心电图、呼吸频率和幅度的影响。结果 盐酸苯海拉明/咖啡因复方（盐酸苯海拉明与咖啡因之比为1:2.4）给药剂量在51、102、204mg/kg时，对小鼠的爬杆能力无明显影响。给药剂量雄性在14.2、28.3、56.6 mg/kg、雌性在5.66、14.2、28.3 mg/kg时，对Beagle犬收缩压、舒张压、平均动脉压、心率、ECG（P波电压、R波电压、T波电压、QRS时间、PR间期、QT间期）、呼吸频率和幅度无明显影响。结论 本实验条件下，单次灌胃给予盐酸苯海拉明/咖啡因复方对实验动物神经系统、心血管系统、呼吸系统无明显影响，提示盐酸苯海拉明/咖啡因复方具有较高的安全性。 |
| 中文关键词:盐酸苯海拉明/咖啡因复方 安全药理学 神经系统 心血管系统 呼吸系统 |
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| Safety pharmacological study of the compound of diphenhydramine hydrochloride and caffeine |
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| Abstract:Objective To provide the reference resource for the safe clinical use of the compound of diphenhydramine hydrochloride and caffeine by observing its effects on the nervous system, cardiovascular system and respiratory system in experimental animals. Methods Single dose of the compound of diphenhydramine hydrochloride and caffeine was given to animals orally. The effects on climbing ability of mice and blood pressure, electrocardiogram, respiration rate and amplitude in beagle dogs were observed and recorded. Results With the dosage of the compound of diphenhydramine hydrochloride and caffeine (diphenhydramine hydrochloride / caffeine ratio is 1/2.4) at 51, 102, 204 mg/kg, there was no significant effect on the climbing ability in mice. With the dosages of 14.2, 28.3, 56.6 mg/kg for male Beagle dogs and 5.66, 14.2, 28.3 mg/kg for female Beagle dogs, no significant effects were observed in systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, ECG（P wave, R wave , T wave, QRS time, PR interval, QT interval）, respiratory rate and amplitude. Conclusion Under the experimental conditions, single oral dose of the compound of diphenhydramine hydrochloride and caffeine has no significant effect on the nervous system, cardiovascular system and respiratory system in experimental animals. Those results suggest that the compound of diphenhydramine hydrochloride and caffeine is a safe agent for clinical use. |
| keywords:compound of diphenhydramine hydrochloride and caffeine safety pharmacology nervous system cardiovascular system respiratory system |
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