| 信号转导和转录激活因子3在肝病中的研究进展 |
| 投稿时间：2021-09-14 修订日期：2022-04-14 点此下载全文 |
| 引用本文：李婷婷,张俊平.信号转导和转录激活因子3在肝病中的研究进展[J].药学实践杂志,2022,40(3):208~212,280 |
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| 基金项目:福建中医药大学高层次人才科研启动资金项目(X2019005) |
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| 中文摘要:信号转导和转录激活因子3（STAT3）是一种重要的转录因子，可被多种细胞因子和生长因子激活，在细胞生长、增殖和分化中发挥关键作用。研究表明，几乎所有的人类肝脏疾病和肝损伤动物模型中均存在STAT3过度激活的现象。通过抑制STAT3的激活可治疗急性肝损伤和肝纤维化，故STAT3抑制剂具有预防和治疗肝脏疾病的潜力。针对STAT3在肝损伤、肝炎、肝再生、肝纤维化和肝癌发生方面的研究进展作一综述。 |
| 中文关键词:STAT3 肝损伤 肝纤维化 肝癌 |
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| Research progress of STAT3 on liver disease |
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| Abstract:Signal transduction and transcriptional activator 3 (STAT3) is an important transcription factor that can be activated by many cytokines and growth factors. STAT3 plays a key role in cell growth, proliferation, and differentiation. It has been shown that hyperactivation of STAT3 exists in almost all animal models of liver injury and human liver diseases. Therefore, inhibition of STAT3 activation might become a promising strategy for prevention and treatment of acute liver injury and liver fibrosis. The research progress of STAT3 on liver injury, hepatitis, liver regeneration, liver fibrosis, and hepatocellular carcinoma were mainly discussed in this review. |
| keywords:STAT3 liver injury liver fibrosis hepatocellular carcinoma |
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