| 复方自微乳中姜黄素和胡椒碱的体外释放研究 |
| 投稿时间：2020-09-27 修订日期：2021-03-23 点此下载全文 |
| 引用本文：任金妹,李曼,王晶,顾申勇.复方自微乳中姜黄素和胡椒碱的体外释放研究[J].药学实践杂志,2022,40(1):66~69,75 |
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| 基金项目:上海市卫生和计划生育委员会科研课题计划资助（20174y0064）；上海市青浦区科技发展基金项目（QKY2019-18）；青浦区卫生健康系统第四轮人才培养（WY2019-17） |
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| 中文摘要:目的 考察复方自微乳中姜黄素和胡椒碱的体外释放行为。方法 采用动态透析法，分别以pH值为4.8、7.5的磷酸盐缓冲液并加入0.75%吐温-80作为漏槽条件，考察姜黄素和胡椒碱的体外释放特性。结果 姜黄素在pH 4.8和pH 7.5释放介质中108 h累积释放百分率分别为94.85%和84.38%。胡椒碱在上述介质中36 h累积释放率分别为92.85%和90.05%。结论 自微乳制剂中姜黄素和胡椒碱具有缓释特性，且在肿瘤酸性环境中释放更多。 |
| 中文关键词:姜黄素 胡椒碱 复方自微乳 体外释放 缓释 |
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| In vitro release study on self-microemulsion of curcumin and piperine |
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| Abstract:Objective To study the release profile of curcumin and piperine from the compound self-microemulsion.Methods The release of curcumin and piperine in vitro was investigated by dynamic dialysis under the condition of phosphate buffer of pH 4.8 and 7.5 with 0.75% Tween-80.Results The cumulative release rates of curcumin in pH 4.8 and pH 7.5 were 94.85% and 84.38% in 108 h, respectively. The cumulative release rates of piperine were 92.85% and 90.05% in 36 h, separately.Conclusion Curcumin and piperine in self-microemulsion have sustained release properties and released more in the acidic environment similar to the environment in tumors. |
| keywords:curcumin piperine self-microemulsifying drug delivery in vitro release sustained release |
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