| 宁夏苦豆子主要活性成分及治疗肝脏疾病的研究进展 |
| 投稿时间：2021-05-11 修订日期：2021-06-22 点此下载全文 |
| 引用本文：权丹妮,徐玥,曲卓,许维恒,张万年,庄春林.宁夏苦豆子主要活性成分及治疗肝脏疾病的研究进展[J].药学实践杂志,2022,40(1):1~5,37 |
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| 基金项目:国家自然科学基金联合基金重点支持项目 (U20A20136) |
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| 中文摘要:苦豆子是豆科槐属植物，为宁夏的道地药材之一。苦豆子有着丰富而复杂的活性成分，主要有生物碱、黄酮、挥发油、甾体、多糖、脂肪酸等。近年来，国内外对苦豆子生物碱开展了大量研究，该类生物碱具有抗肝炎、抗肝纤维化、抗肝硬化、抗肝衰竭、抗肝癌等药理作用，其中，苦参碱相关药物已经获批在临床用于治疗乙型肝炎病毒感染等疾病。鉴于苦豆子在肝脏疾病治疗中的药用价值，对苦豆子主要活性成分进行综述，重点阐述其治疗肝脏疾病的研究进展。 |
| 中文关键词:宁夏苦豆子 活性成分 肝脏疾病 研究进展 |
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| Research progresses on the main active components in Ningxia Sophora alopecuroides and the therapeutic activities for liver diseases |
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| Abstract:Sophora alopecuroides, a plant of the family Leguminosae, is one of the Daodi herbs in Ningxia. The active constituents of Sophora alopecuroides are abundant and complex, including alkaloids, flavonoids, volatile oils, steroids, polysaccharides, fatty acids and so on. In recent decades, a great number of domestic and overseas studies have been carried out on Sophora alopecuroides alkaloids, which have anti-hepatitis, anti-liver fibrosis, anti-cirrhosis, anti-liver failure and anti-liver cancer and other pharmacological effects. Clinically, Matrine-related drugs are used to treat hepatitis B virus infection and other diseases. This review aims to summarize the main active ingredients of Sophora alopecuroides, mainly focusing on the research progress in their treatment activities for liver diseases. |
| keywords:Ningxia Sophora alopecuroides active constituents hepatic disease research progress |
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