| 胱抑素C水平与替考拉宁血谷浓度的关系研究 |
| 投稿时间：2021-03-18 修订日期：2021-09-01 点此下载全文 |
| 引用本文：戴青,程林,胡显飞,刘芳.胱抑素C水平与替考拉宁血谷浓度的关系研究[J].药学实践杂志,2021,39(6):569~572 |
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| 基金项目:陆军军医大学优秀人才库重点扶持对象苗圃人才项目（XZ-2019-505-073）；重庆市科卫联合面上项目（2021MSXM218） |
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| 中文摘要:目的 探讨胱抑素C水平与替考拉宁血浆谷浓度的关系，为临床替考拉宁的合理应用提供依据。方法 回顾性分析2017年10月至2020年7月我院收治的使用替考拉宁患者的临床资料。考察替考拉宁血浆谷浓度的分布情况，比较不同胱抑素C水平下替考拉宁血浆谷浓度，Logistic回归分析替考拉宁谷浓度不达标（<15 μg/ml）的影响因素。结果 共入组98例患者，141个谷浓度，其中男65例、女33例，年龄19～94（52.2±16.2）岁。替考拉宁血浆谷浓度为11.51 (8.35，19.07) μg/ml，范围为3.57～41.93 μg/ml，谷浓度<15 μg/ml者95例次（67.38%）。胱抑素C浓度高于正常值上限（>1.05 mg/L）时，替考拉宁谷浓度为11.37 (8.96，20.52) μg/ml，明显高于胱抑素C浓度在正常范围内的8.68 (6.34，11.79) μg/ml（Z=?2.636，P<0.05）。Logistic回归分析显示胱抑素C水平为替考拉宁谷浓度不达标的影响因素（OR=1.529，95% CI=1.001～2.336，P<0.05）。结论 胱抑素C浓度高于正常值上限时替考拉宁谷浓度明显升高，是替考拉宁谷浓度不达标的影响因素，临床上可以考虑将其作为替考拉宁剂量调整的参考指标。 |
| 中文关键词:替考拉宁 感染 治疗药物监测 胱抑素C |
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| Study on the relationship between cystatin C level and the plasma trough concentration of teicoplanin |
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| Abstract:Objective To investigate the relationship between cystatin C level and the plasma trough concentration of teicoplanin, so as to provide a reference for the rational application of teicoplanin in clinical practice. Methods The clinical data of the patients receiving teicoplanin, who admitted to our hospital from October 2017 to July 2020 were retrospectively analyzed. The distribution of teicoplanin concentration, the difference of teicoplanin concentration under different cystatin C level, and influence factors for teicoplanin concentration (<15 μg/ml) were analyzed. Results A total of 98 patients including 65 males and 33 females, aged 19 to 94 (52.2±16.2) years old, with 141 trough concentrations were enrolled. The trough concentration of teicoplanin was 11.51 (8.35, 19.07) μg/ml, and the range was 3.57-41.93 μg/ml. 95 cases (67.38%) had teicoplanin concentration <15 μg/ml. When the concentration of cystatin C was >1.05 mg/L, the trough concentration of teicoplanin were 11.37 (8.96, 20.52) μg/ml, significantly higher than those when the concentration of cystatin C was in normal [8.68 (6.34, 11.79) μg/ml, Z=?2.636, P<0.05]. Logistic regression analysis showed that cystatin C level was the influencing factor for teicoplanin trough concentration does not meet the standard (OR=1.529, 95%CI=1.001-2.336, P<0.05). Conclusion The concentration of teicoplanin is significantly increased when the cystatin C level is higher than the normal. Cystatin C level is the influence factor for teicoplanin trough concentration not meeting the standard. The cystatin C level may be considered as a reference for teicoplanin dosage adjustment in clinical practice. |
| keywords:teicoplanin infection therapeutic drug monitoring cystatin C |
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