| 临床药师参与一例丙戊酸钠中毒患者救治过程分析 |
| 投稿时间：2021-01-17 修订日期：2021-08-30 点此下载全文 |
| 引用本文：张井明,陆文杰,周书琴,赵健,万红虹,庄育刚.临床药师参与一例丙戊酸钠中毒患者救治过程分析[J].药学实践杂志,2021,39(6):566~568 |
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| 基金项目:国家自然科学基金项目（81971804） |
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| 中文摘要:目的 通过分析临床药师参与一例丙戊酸钠中毒患者的救治过程，探讨临床药师在药物中毒救治过程中的作用。方法 临床药师通过测定丙戊酸钠血药浓度指导医生诊断病情，初期高浓度时先以连续静脉-静脉血液透析-滤过（CVVHDF）清除游离药物，后期联合血液灌流进行结合态丙戊酸钠清除。结果 首次CVVHDF时血药浓度下降一半，随后两次血液灌流后血药浓度明显下降，稳定观察，血药浓度维持较低水平后予以痊愈出院，病程5 d。结论 药师参与的血药浓度监测下的血液净化方案的实施，有助于药物过量的抢救，值得推广。 |
| 中文关键词:丙戊酸钠 中毒 血药浓度监测 血液净化 血液灌流 临床药师 |
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| Analysis of clinical pharmacists participating in the treatment of a case of sodium valproate poisoning |
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| Abstract:Objective To explore the role of clinical pharmacists in the treatment of drug poisoning by analyzing the clinical pharmacist's participation in the treatment of a patient with sodium valproate poisoning. Methods Clinical pharmacists measured the plasma concentration of sodium valproate to inform the doctor to diagnose illnesses. At the initial stage when the concentration is high, to eliminate the free drug by continuous venous-venous hemodialysis-filtration (CVVHDF). Then, the combined drug was cleared by hemoperfusion (HP). Results The blood concentration dropped by half at the first CVVHDF and decreased obviously after two HPs. After stable observation in five days’ course of disease, the blood concentration was maintained at a low level and the patient was cured and discharged. Conclusion The implementation of the blood purification program under the monitoring of the blood drug concentration with the participation of pharmacists is helpful for the rescue of drug overdose and is worthy of promotion. |
| keywords:sodium valproate poisoning blood drug concentration monitoring blood purification hemoperfusion clinical pharmacists. |
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