| 脓毒症生物标志物的最新进展 |
| 投稿时间：2021-05-12 修订日期：2021-10-07 点此下载全文 |
| 引用本文：赵景昕,缪朝玉,徐添颖.脓毒症生物标志物的最新进展[J].药学实践杂志,2021,39(6):491~498 |
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| 基金项目:国家自然科学基金重点项目(81730098)；海军军医大学高等级成果培植计划(2018-CGPZ-A03) |
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| 中文摘要:脓毒症可以导致危及生命的器官功能障碍，是危重患者死亡的主要原因之一。脓毒症的早期诊断与正确治疗是降低病死率的关键，但目前尚无诊断的金标准。理想的脓毒症生物标志物应该具有早期诊断和预测不良预后的能力，且具有较好的敏感性和特异性。脓毒症的候选生物标志物众多，本文重点综述了急性期蛋白、可溶性受体、非编码RNA和其他近期关注度较高的候选标志物的最新进展。 |
| 中文关键词:脓毒症 生物标志物 诊断 预后 |
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| Recent advances in biomarkers of sepsis |
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| Abstract:Sepsis can cause life-threatening organ dysfunction and is one of the leading causes of death in critically ill patients. Early diagnosis and correct treatment of sepsis are the key to reducing the fatality, however, there is no golden standard for diagnosis at present. The ideal sepsis biomarker can be used for early diagnosis and predicting poor prognosis with good sensitivity and specificity. There are many candidate biomarkers for sepsis. This article reviews the latest developments on acute phase proteins, soluble receptors, non-coding RNAs and other candidate biomarkers of sepsis that attracted more recent attention. |
| keywords:sepsis biomarker diagnosis prognosis |
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