| cGAS-cGAMP-STING通路在抗病毒中的作用 |
| 投稿时间：2020-08-09 修订日期：2020-12-25 点此下载全文 |
| 引用本文：张倩,章越凡,李铁军.cGAS-cGAMP-STING通路在抗病毒中的作用[J].药学实践杂志,2021,39(6):487~490,498 |
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| 基金项目:上海市浦东新区重要薄弱学科建设（临床药学，PWZbr2017-16）；上海市浦东新区卫生系统新兴、交叉学科（精准临床药学，PWXx2020-03） |
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| 中文摘要:先天性免疫是宿主防御病原体入侵机体的第一道防线。胞质中异常核酸的检测表明一些保守的病原相关分子模式（pathogen associated molecular patterns）引发了Ⅰ型干扰素（IFN）介导的先天性免疫反应。DNA传感器环鸟苷酸-腺苷酸合成酶(cGAS）识别并结合宿主或病原体胞质DNA，促使第二信使环鸟苷酸-腺苷酸（cGAMP）的合成并触发干扰素基因刺激蛋白(STING）依赖性下游信号传导。该文简述了cGAS-cGAMP-STING通路及其在抗病毒研究中的最新进展，为开展病毒防治研究提供新思路，为抗病毒药物的研发提供新的方向。 |
| 中文关键词:环鸟苷酸-腺苷酸合成酶 环鸟苷酸-腺苷酸 干扰素基因刺激蛋白 抗病毒 |
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| Role of cGAS-cGAMP-STING pathway in antivirus |
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| Abstract:Innate immunity is the host's first line defense against pathogens invading to the body. Detection of abnormal nucleic acids in the cytoplasm showed that some conserved pathogen associated molecular patterns (PAMPS) triggered type I interferon (IFN) -mediated innate immune responses. The DNA sensor— cGAS (cGAMP Synthase) recognizes and binds to host or pathogen cytoplasmic DNA, promotes the formation of the second messenger cGAMP (cyclic GMP-AMP), and triggers STING (stimulator of interferon genes) dependent downstream signaling. Here we briefly describe the latest progress of the cGAS-cGAMP-STING pathway and its important role in antivirus, and provide new ideas for virus prevention research and new direction for the development of antiviral drugs. |
| keywords:cGAS cGAMP STING antivirus |
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