| 儿童哮喘辅以布地奈德的治疗效果及其用药后1～2年对生长发育的影响 |
| 投稿时间：2021-01-12 修订日期：2021-04-22 点此下载全文 |
| 引用本文：郝秀丽,谢放,闫学平.儿童哮喘辅以布地奈德的治疗效果及其用药后1～2年对生长发育的影响[J].药学实践杂志,2021,39(5):479~482 |
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| 基金项目:中国中医科学院中医基础理论研究所第十一批(2017年度)自主选题“院所协同创新科研专项基金”项目(YZ-1761) |
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| 中文摘要:目的 探讨吸入布地奈德混悬液用于儿童哮喘治疗中的效果及其用药后1～2年对生长发育的影响。方法 选择于2016年10月至2017年1月收诊的68例儿童哮喘患者，均为急性发作并持续用药，分为两组：34例应用硫酸沙丁胺醇吸入气雾剂治疗的患者为对照组，34例应用吸入布地奈德混悬液联合硫酸沙丁胺醇吸入气雾剂治疗的患者为观察组。比较两组儿童哮喘急性发作期患者的白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、超敏-C反应蛋白（hs-CRP）、最大呼吸流量、IS最大呼气量、调节性B细胞比例、喘憋消失时间、气促缓解时间、湿啰音消失时间、咳嗽消失时间，并对比随访2年后的生长发育指标。结果 用药结束，观察组的IL-6、TNF-α、hs-CRP、调节性B细胞比例、喘憋消失时间、气促缓解时间、湿啰音消失时间、咳嗽消失时间均低于对照组（P<0.05）；观察组的最大呼吸流量、IS最大呼气量高于对照组（P<0.05）。观察组患儿随访结束后的生长激素水平、身高和体重均低于对照组（P<0.05）。结论 吸入用布地奈德混悬液联合硫酸沙丁胺醇吸入气雾剂雾化吸入疗法可缓解患儿的炎症反应，改善患儿的肺功能及免疫功能，加快临床症状的消失，但一定程度上会影响患儿的生长发育。 |
| 中文关键词:调节性B细胞 儿童哮喘急性发作 硫酸沙丁胺醇吸入气雾剂 吸入用布地奈德混悬液 生长发育 |
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| The therapeutic effect of budesonide on childhood asthma and its influence on growth and development 1 to 2 years after the treatment |
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| Abstract:Objective To explore the effect of budesonide suspension for inhalation in the treatment of childhood asthma and its influence on growth and development in 1-2 years.Methods The 68 children with asthma admitted to our hospital from October 2016 to January 2017 were selected. Every patient had acute attacks and received continued medication. 34 patients treated with salbutamol sulfate inhaled aerosol were used as the control group. 34 patients treated with budesonide suspension combined with salbutamol sulfate aerosol were classified as the observation group. The interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α), high-sensitivity-C-reactive protein (hs-CRP), maximum respiratory flow, IS maximum expiratory volume, regulatory B cell ratio, wheezing disappearance time, shortness of breath relief time, wet rales disappearing time, cough disappearing time, and the two year follow-up indicators of growth and development were compared.Results After medication, IL-6, TNF-α, hs-CRP, regulatory B cell ratio, wheezing disappearance time, shortness of breath relief time, moist rales disappearance time, and cough disappearance time were lower in the observation group(P<0.05). The maximum respiratory flow and IS maximum expiratory volume in the observation group were higher than those in the control group (P<0.05). The GH level, height, and weight obtained from two year follow up in the observation group were lower than those in the control group (P<0.05).Conclusion Budesonide suspension combined with salbutamol sulfate aerosol inhalation therapy can alleviate the inflammatory reaction, improve the lung function and immune function of children, and accelerate the disappearance of clinical symptoms, but it will affect the growth and development of children to a certain extent. |
| keywords:regulatory B cells acute asthma attack in children salbutamol sulfate inhalation aerosol budesonide suspension for inhalation growth and development |
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