| 吩嗪类衍生物的抗真菌活性研究 |
| 投稿时间：2021-03-26 修订日期：2021-05-07 点此下载全文 |
| 引用本文：邱丽娟,巣雯,石安喆,阎澜,吕权真,姜远英.吩嗪类衍生物的抗真菌活性研究[J].药学实践杂志,2021,39(3):249~254 |
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| 基金项目:上海市青年科技英才扬帆计划资助(19YF1458800) |
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| 中文摘要:目的 研究吩嗪类衍生物的抗真菌活性。方法 利用微量液基稀释法考察吩嗪类衍生物的体外抗真菌活性；利用棋盘式微量稀释法检测吩嗪类衍生物与氟康唑合用对常见临床耐药菌的抗真菌活性；在菌丝诱导条件下考察吩嗪衍生物对白念珠菌菌丝形成的抑制效果。结果 吩嗪类衍生物单用对临床常见条件致病真菌白念珠菌没有明显抗真菌活性；吩嗪衍生物-17与氟康唑合用有显著抗白念珠菌活性；吩嗪衍生物-17与氟康唑合用可以明显抑制白念珠菌菌丝生长。结论 筛选获得了与氟康唑合用具有抗真菌活性的吩嗪类衍生物-17，为抗真菌药物研发和克服真菌耐药提供了新思路。 |
| 中文关键词:吩嗪类化合物 白念珠菌 抗真菌活性 菌丝形成 |
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| Study on the antifungal activity of phenazine derivatives |
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| Abstract:Objective To study the antifungal activity of phenazines derivatives.Methods The anti-fungal activity of phenazine compounds was evaluated initially with micro-liquid dilution. No significant antifungal activity against Candida albicans was found. Then, with the combination of phenazine compounds and fluconazole, the anti-fungal activity against fluconazole-resistant C. albicans was detected.Results The phenazine-17 had significant antifungal activity when combined with fluconazole through the inhibition of hyphae formation.Conclusion This study provides a new idea for the development of antifungal drugs and the solution of antifungal drug resistance. |
| keywords:phenazine derivatives Candida albicans antifungal activity hyphae formation |
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