| 银连祛风汤治疗慢性荨麻疹的疗效观察及其对IgE和T细胞亚群水平的影响 |
| 投稿时间：2020-03-16 修订日期：2020-06-04 点此下载全文 |
| 引用本文：朱展慧,李军,盛国荣.银连祛风汤治疗慢性荨麻疹的疗效观察及其对IgE和T细胞亚群水平的影响[J].药学实践杂志,2021,39(1):82~85,93 |
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| 基金项目:江苏省药学会-奥赛康医院药学基金（A201952） |
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| 中文摘要:目的 观察银连祛风汤治疗慢性荨麻疹（CU）的临床效果及其对患者IgE、T细胞亚群（CD4+、CD8+）水平的影响。方法 将96例CU患者随机分为治疗组（48例）和对照组（48例），治疗组和对照组分别内服银连祛风汤和地氯雷他啶分散片，连续用药8周。对两组患者治疗前后临床症状积分、中医证候积分及生活质量[皮肤病生活质量指数(DLQI)]分别进行评价；IgE含量用ELISA法测定，CD4+、CD8+含量用流式细胞仪测定。观察临床治疗效果并统计不良反应发生率。结果 治疗前，治疗组和对照组患者临床症状积分、中医证候积分、DLQI和IgE、CD4+、CD8+水平、CD4+/CD8+比值分别比较，差异均无统计学意义（P>0.05）。治疗后，治疗组和对照组临床症状积分、中医证候积分、DLQI均明显降低，治疗组降低程度优于对照组，差异均有统计学意义（P<0.01）；治疗组和对照组CD4+水平、CD4+/CD8+比值明显升高，IgE、CD8+水平明显降低，治疗组以上各指标的改变程度优于对照组，差异均有统计学意义（P<0.01）。治疗组和对照组有效率分别为91.67%、77.08%，不良反应发生率分别为6.25%、20.83%，差异均有统计学意义（P<0.05）。结论 银连祛风汤可有效调节CU患者的细胞免疫功能，改善疾病症状和生活质量，临床治疗效果明显，不良反应少而轻，值得临床推广使用。 |
| 中文关键词:慢性荨麻疹 银连祛风汤 临床疗效 IgE CD4+ CD8+ |
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| Effects of Yinlian Qufeng decoction on chronic urticaria and the level of IgE and T cell subsets |
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| Abstract:Objective To study the clinical effects of Yinlian Qufeng decoction in the treatment of chronic urticaria (CU) and the effects on the changes of serum IgE and T cell subsets (CD4+, CD8+).Methods 96 patients were randomly divided into two groups, treatment group and control group, with 48 cases in each group. The treatment group was treated with Yinlian Qufeng decoction, while the control group was treated with desloratadine dispersible tablets for 8 weeks. The clinical symptom score, TCM syndrome score and quality of life [skin disease quality of life index (DLQI)] of the two groups were evaluated before and after treatment. The serum levels of IgE and CD4+ and CD8+ were measured by ELISA and flow cytometry. Clinical effect was observed and the rate of adverse reactions was counted.Results There was no statistically difference between two groups in clinical symptom scores, TCM syndrome scores, DLQI, the levels of IgE, CD4+, CD8+, and the ratio of CD4+/CD8+ before treatment (P>0.05). After treatment, the clinical symptoms, TCM syndromes and DLQI were reduced in both groups. The treatment group had lower scores than that in control group with statistical significance（P < 0.05). CD4+ level and ratio of CD4+/CD8+ were increased, while IgE and CD8+ levels were decreased in both groups after treatment with statistical significance (P < 0.01). The changes of above indexes in the treatment group were better than those in the control group with statistical significance (P < 0.01). The effective rates of the two groups were 91.67% and 77.08% and rates of adverse reactions were 6.25% and 20.83% separately with statistical difference (P < 0.05).Conclusion Yinlian Qufeng decoction can effectively regulate the cellular immune function, alleviate the disease symptoms and improve life quality with few adverse reactions. This decoction deserves the promotion for clinical application. |
| keywords:chronic urticaria Yinlian Qufeng decoction clinical effect IgE CD4+ CD8+ |
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