| 红景天苷单体与坤复康片大鼠口服药动学特征的比较 |
| 投稿时间：2020-06-10 修订日期：2020-10-10 点此下载全文 |
| 引用本文：刘昕竹,徐人杰,冯城,魏昕.红景天苷单体与坤复康片大鼠口服药动学特征的比较[J].药学实践杂志,2021,39(1):49~52 |
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| 基金项目:上海交通大学医学院医院药学科研基金（JDYX2017QW005）；上海交通大学医学院附属新华医院院基金（XH2053） |
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| 中文摘要:目的 研究红景天苷单体和坤复康片在大鼠体内的药动学特征，探讨药物配伍对红景天苷单体在大鼠体内过程的影响。方法 用LC/MS/MS法测定红景天苷和坤复康片在大鼠体内的血药浓度，估算两者的药动学参数。结果 红景天苷和坤复康在大鼠体内主要药动学参数AUC0-t分别为（587.11±35.02）和（956.35±47.65）ng·h/ml；cmax分别为（85.81±15.66）和（143.86±46.91）ng/ml，两者有显著差异。结论 坤复康片中的其他成分会影响红景天苷的吸收、分布和排泄。 |
| 中文关键词:坤复康 红景天苷 口服 药动学 |
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| Comparison of the pharmacokinetic characteristics of pure salidroside and Kunfukang pills after oral administration |
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| Abstract:Objective To study the pharmacokinetic differences of pure salidroside and Kunfukang pills in rats and explore the pharmacokinetic changes of salidroside as a pure form or in the mixture.Methods The rats were divided into two groups. One group received pure salidroside and the other was administrated with kunfukang pills. Concentrations of salidroside in both groups were determined by LC/MS/MS method. The main pharmacokinetic parameters were calculated.Results AUC0-t of salidroside was (587.11±35.02) in pure salidroside group and (956.35±47.65)ng·h/ml in Kunfukang group. cmax was (85.81±15.66) and (143.86±46.91)ng/ml separately, with significant difference.Conclusion The results indicated that other components in kunfukang pills had influence on the absorption, distribution and elimination of salidroside. |
| keywords:Kunfukang salidroside oral administration pharmacokinetics |
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