| 胰岛素超多孔水凝胶控释制剂的制备及其检测 |
| 投稿时间：2020-05-30 修订日期：2020-12-23 点此下载全文 |
| 引用本文：胡等慧,王秀丽,任蕾蕾.胰岛素超多孔水凝胶控释制剂的制备及其检测[J].药学实践杂志,2021,39(1):44~48,76 |
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| 中文摘要:目的 制备一种可实现控释的超多孔水凝胶，以胰岛素为模型药，考察超多孔水凝胶的载药、释药性能，初探给药途径及药效。方法 采用聚合物互穿网络法制备超多孔水凝胶（SPH-IPN）；通过傅立叶变换红外光谱和核磁共振碳谱考察凝胶的结构；通过测定溶胀比、孔隙率考察凝胶的性能；并以胰岛素为模型药研究超多孔水凝胶的载药量及载药后的药效。结果 所制得的超多孔水凝胶胰岛素的载药量为3.19%。通过动物皮下包埋的预实验结果可以看到，载胰岛素冻干凝胶在1～24 h对糖尿病大鼠的降糖效果较好。结论 冻干胰岛素超多孔水凝胶皮下包埋，可实现24 h血糖值稳定，具有很好的控释效果。 |
| 中文关键词:超多孔水凝胶 胰岛素 皮下埋植 |
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| Preparation and detection of controlled release insulin ultra-porous hydrogel |
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| Abstract:Objective To prepare an ultra-porous hydrogel capable of controlled release and investigate the drug loading, releasing, administration route and efficacy with insulin as a model drug.Methods The polymer interpenetrating network method was used to prepare ultra-porous hydrogels (SPH-IPN). Insulin was selected as a model drug to study the drug loading and efficacy. Fourier transform infrared spectroscopy and nuclear magnetic resonance carbon spectroscopy were used to investigate the structure of the gel. The swelling ratio and porosity were measured to evaluate the gel performance.Results The drug loading capacity of insulin ultra-porous hydrogel was 3.19%. The insulin-loaded freeze-dried gel exhibited good hypoglycemic effect on diabetic rats in 1−24 hours from the experimental results on rats with subcutaneous implantation.Conclusion The subcutaneously embedded lyophilized insulin ultra-porous hydrogel provided good controlled release efficacy. It maintained stable blood glucose levels within 24 hours. |
| keywords:ultra- porous hydrogel insulin subcutaneous implantation |
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