| 信号转导及转录激活因子3抑制剂研究进展 |
| 投稿时间：2020-06-07 修订日期：2020-08-28 点此下载全文 |
| 引用本文：刘航,赵庆杰,徐伟.信号转导及转录激活因子3抑制剂研究进展[J].药学实践杂志,2021,39(1):4~8 |
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| 中文摘要:信号转导及转录激活因子3(signal transducer and activator of transcription 3，STAT3)是一种信号转录蛋白。STAT3的异常激活与细胞的增殖、分化、癌变等密切相关，其在乳腺癌、胰腺癌、淋巴癌、肺癌等癌干细胞中存在异常表达。因此，抑制STAT3的异常表达已成为抗炎免疫、抗肿瘤治疗的一种新思路。 |
| 中文关键词:STAT3 抑制剂 抗肿瘤 |
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| Research progress of STAT3 inhibitors |
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| Abstract:Signal transducer and activator of transcription 3 (STAT3) is a signal transcription protein that exists in the cytoplasm. The abnormal activation of STAT3 is closely related to cell proliferation, differentiation, and canceration. It has abnormal expression in cancer stem cells such as breast cancer, pancreatic cancer, lymphoma, and lung cancer. Therefore, inhibiting the abnormal expression of STAT3 has become a new approach for antitumor therapy. |
| keywords:STAT3 inhibitor antitumor |
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