| 安罗替尼上市后不良反应文献回顾性分析 |
| 投稿时间：2020-07-18 修订日期：2020-09-07 点此下载全文 |
| 引用本文：廖小兰,汪滢,黄爱文,赖彦岚,赵丽君,宋洪涛.安罗替尼上市后不良反应文献回顾性分析[J].药学实践杂志,2020,38(6):558~562 |
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| 中文摘要:目的 通过分析安罗替尼致不良反应的临床表现、发生特点、处置及转归情况，以期为临床安全合理应用安罗替尼提供有价值的参考依据。方法 通过检索Web of Science、Pubmed、Wiley Online Library、中国知网、万方和维普数据库中有关安罗替尼上市后不良反应的病例报道，筛选后采用回顾性分析方法，对患者的基本情况、不良反应发生时间、特点、处理、转归以及累及的器官/系统等进行整理分析。结果 共收集20例病例，男性10例，女性10例，年龄中位数为63.5岁（36～76岁）。不良反应多发生在用药后2个月内，共发生52例次，累及9个系统/器官，其中以血管与淋巴管类疾病最为常见（21.2%）。结论 在安罗替尼临床推广应用后，心血管系统不良反应发生率较高，用药过程应密切监测，同时注意监测说明书中提及的和潜在的不良反应。 |
| 中文关键词:安罗替尼 药物不良反应 回顾性分析 |
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| Literature review and analysis of adverse drug reactions of anlotinib |
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| Abstract:Objective To review and analysis the clinical manifestations, occurrence rules, treatment and outcomes of adverse drug reactions caused by anlotinib in order to provide reference for safety and reasonable use of anlotinib in clinical practice.Methods The cases reports of anlotinib were searched in Web of Science, Pubmed, Wiley Online Library, CNKI, Wanfang and VIP. The basic patient information, adverse reaction time, characters, treatment, outcomes and involved systems or organs were collected and analyzed.Results A total of 20 cases were collected, 10 females and 10 males, with a median age of 63.5(36～76 years old). Adverse drug reactions mostly occurred within 2 months after the medication. 52 cases occurred in total, involving 9 systems/organs, of which blood and lymphatic system disorders (all were hypertension) were the most common (21.2%).Conclusion After the administration of anlotinib, the incidence rate of adverse reactions in the cardiovascular system is relatively high. The medication process should be closely monitored, and attention should be paid to monitoring the potential adverse reactions mentioned in the instructions. |
| keywords:anlotinib adverse drug reactions retrospective analysis |
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