| 以硝化纤维为膜材的伤口敷料的制备及处方优化 |
| 投稿时间：2019-10-25 修订日期：2020-03-16 点此下载全文 |
| 引用本文：张灵娜,王天宇,洪婉凤,陶春,宋洪涛.以硝化纤维为膜材的伤口敷料的制备及处方优化[J].药学实践杂志,2020,38(4):301~306 |
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| 基金项目:2016年度军队后勤科研项目（CNJ16C015） |
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| 中文摘要:目的 制备一种以硝化纤维为膜材的创伤敷料，并对其处方进行优化。方法 对市售产品进行部分分析，采用硝化纤维作为成膜材料，以苯甲醇为抑菌剂，蓖麻油为增塑剂，棕榈酸异丙酯为皮肤柔润剂，樟脑作为芳香剂，以异丙醇、乙酸乙酯、乙酸丁酯为挥发溶剂制备创伤敷料。分别对所成膜的抗张强度、断点伸长百分率、透气防水性能等进行考察评价。结果 所制备液体创伤敷料成膜性能良好，确定硝化纤维的最终使用量为6%、蓖麻油的使用量为4%。结论 研究所制得的液体创伤敷料成膜性好，有良好的机械性能，并具备较好的防水能力及一定的透气性能。 |
| 中文关键词:创伤敷料 硝化纤维 处方优化 |
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| Preparation and formulation optimization of wound dressings with nitrocellu-lose as membrane material |
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| Abstract:Objective To prepare a wound dressing using nitrocellulose as a membrane and optimize its formulation.Methods Partial analysis was performed on commercial available products. The wound dressings were prepared by using nitrocellulose as a film-forming material, benzyl alcohol as a bacteriostatic agent, castor oil as a plasticizer, isopropyl palmitate as a skin emollient, camphor as a fragrance, and isopropyl alcohol, ethyl acetate and butyl acetate as volatile solvent. The tensile strength, breakpoint elongation percentage, breathability and waterproof performance were tested and evaluated.Results The film-forming performance of the prepared liquid wound dressing was good. The final use amount of nitrocellulose was determined to be 6%. The use amount of plasticizer castor oil was determined to be 4%.Conclusion The prepared liquid wound dressing has good film-forming property, good mechanical property, good waterproof and certain breathability. |
| keywords:wound dressing nitrocellulose , formulation optimization |
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