| 综合干预对肿瘤科特殊使用级抗菌药物应用及细菌耐药性的影响 |
| 投稿时间：2019-08-16 修订日期：2020-02-18 点此下载全文 |
| 引用本文：汪涛,周保柱,宇方,朱捷,王影.综合干预对肿瘤科特殊使用级抗菌药物应用及细菌耐药性的影响[J].药学实践杂志,2020,38(2):189~192 |
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| 基金项目:我院抗菌药物在线分析系统的开发与应用（编号：2012YG05） |
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| 中文摘要:目的 探讨肿瘤科特殊使用级抗菌药物应用的综合干预及对细菌耐药性的影响，并分析综合干预后的效果。方法 以肿瘤科2017年1~6月出院的63例患者病历作为对照组，2018年1~6月出院的61例患者病历作为干预组，比较干预前后特殊使用级抗菌药物相关指标的变化。结果 经过综合干预，肿瘤科特殊使用级抗菌药物网络会诊通过率由65.34%上升到98.00%，有显著性差异（P<0.05）；利奈唑胺、氨曲南、卡泊芬净及伏立康唑的药物利用指数(DUI)值由大于1降至小于1；抗菌药物单药使用率显著增加，抗菌药物多药使用率显著降低（P<0.05）；主要病原菌为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、金黄色葡萄球菌、白假丝酵母菌和光滑假丝酵母菌，其构成比例变化不大；除肺炎克雷伯菌对亚胺培南耐药率增加了16.67%外，其他病原菌耐药率均处于下降趋势。结论 综合干预使肿瘤科特殊使用级抗菌药物临床应用情况日趋合理。 |
| 中文关键词:特殊使用级抗菌药物 细菌耐药性 肿瘤科 综合干预 |
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| Effects of comprehensive intervention on the application of special-use-grade antibacterial agents and on bacterial resistance in oncology department |
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| Abstract:Objective To investigate the comprehensive intervention of special-use-grade antibacterial agents and their effects on bacterial resistance in oncology department, and analyze the effects of comprehensive intervention.Methods The medical records of 63 patients discharged from January to June 2017 were used as the control group, and the medical records of 61 patients discharged from January to June 2018 were used as the intervention group. The changes in the indicators of special-use-grade antibacterial agents before and after the intervention were compared.Results After comprehensive intervention, the pass rate of online consultation of special-use-grade antibacterial agents increased from 65.34% to 98.00%, with a statistical difference (P<0.05). DUI values of linezolid, amitraconam, carbophenazim and voriconazole decreased from more than 1 to less than 1. The usage rate of single use antibacterial agents was significantly increased, and the usage rate of combination of antibacterial agents was significantly decreased (P<0.05). Main pathogenic bacteria for escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa, staphylococcus aureus, white smooth candida yeast and candida, and their constituent ratio had no significant change. Except for klebsiella pneumoniae, the resistance rate of imipenem increased by 16.67%, while resistance rate of other pathogens is in a downward trend.Conclusion The comprehensive intervention makes the clinical application of special-use-grade antibacterial agents in oncology department increasingly reasonable. |
| keywords:special-use-grade antibacterial agents bacterial resistance oncology department comprehensive intervention |
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